Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122

We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-b...

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Detalles Bibliográficos
Autores principales: Li, Lei, Li, Xiao, Huang, Xin, Jiang, Weilai, Liu, Letian, Hou, Chunning, Yang, Yanqing, Zhang, Lei, Zhang, Xiaodan, Ye, Longwei, Yuan, Jie, Li, Guolin, Sun, Haiming, Mao, Limin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019385/
https://www.ncbi.nlm.nih.gov/pubmed/29769413
http://dx.doi.org/10.1042/BSR20180311
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author Li, Lei
Li, Xiao
Huang, Xin
Jiang, Weilai
Liu, Letian
Hou, Chunning
Yang, Yanqing
Zhang, Lei
Zhang, Xiaodan
Ye, Longwei
Yuan, Jie
Li, Guolin
Sun, Haiming
Mao, Limin
author_facet Li, Lei
Li, Xiao
Huang, Xin
Jiang, Weilai
Liu, Letian
Hou, Chunning
Yang, Yanqing
Zhang, Lei
Zhang, Xiaodan
Ye, Longwei
Yuan, Jie
Li, Guolin
Sun, Haiming
Mao, Limin
author_sort Li, Lei
collection PubMed
description We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-ber-PC for the co-delivery of BER and miR-122. mr-ber-PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and miR-122 to significantly increase the anticancer therapeutic effects.
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spelling pubmed-60193852018-07-05 Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122 Li, Lei Li, Xiao Huang, Xin Jiang, Weilai Liu, Letian Hou, Chunning Yang, Yanqing Zhang, Lei Zhang, Xiaodan Ye, Longwei Yuan, Jie Li, Guolin Sun, Haiming Mao, Limin Biosci Rep Research Articles We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-ber-PC for the co-delivery of BER and miR-122. mr-ber-PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and miR-122 to significantly increase the anticancer therapeutic effects. Portland Press Ltd. 2018-06-27 /pmc/articles/PMC6019385/ /pubmed/29769413 http://dx.doi.org/10.1042/BSR20180311 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Li, Lei
Li, Xiao
Huang, Xin
Jiang, Weilai
Liu, Letian
Hou, Chunning
Yang, Yanqing
Zhang, Lei
Zhang, Xiaodan
Ye, Longwei
Yuan, Jie
Li, Guolin
Sun, Haiming
Mao, Limin
Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122
title Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122
title_full Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122
title_fullStr Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122
title_full_unstemmed Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122
title_short Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122
title_sort synergistic anticancer effects of nanocarrier loaded with berberine and mir-122
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019385/
https://www.ncbi.nlm.nih.gov/pubmed/29769413
http://dx.doi.org/10.1042/BSR20180311
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