Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome

• Embryonal rhabdomyosarcoma of the uterine cervix and ovarian Sertoli-Leydig cell tumors are associated with DICER1 mutation; • DICER1-associated tumors should prompt genetic counseling and testing; • Somatic and germline genetic mutation profiles can be used to differentiate second primary from re...

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Detalles Bibliográficos
Autores principales: Cowan, Matthew, Suntum, Tara, Olivas, Andrea D., Perpich, Melody, Applebaum, Mark A., Lastra, Ricardo R., Yamada, S.Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019406/
https://www.ncbi.nlm.nih.gov/pubmed/30014022
http://dx.doi.org/10.1016/j.gore.2018.06.008
Descripción
Sumario:• Embryonal rhabdomyosarcoma of the uterine cervix and ovarian Sertoli-Leydig cell tumors are associated with DICER1 mutation; • DICER1-associated tumors should prompt genetic counseling and testing; • Somatic and germline genetic mutation profiles can be used to differentiate second primary from recurrent tumors.

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