Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome

• Embryonal rhabdomyosarcoma of the uterine cervix and ovarian Sertoli-Leydig cell tumors are associated with DICER1 mutation; • DICER1-associated tumors should prompt genetic counseling and testing; • Somatic and germline genetic mutation profiles can be used to differentiate second primary from re...

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Detalles Bibliográficos
Autores principales: Cowan, Matthew, Suntum, Tara, Olivas, Andrea D., Perpich, Melody, Applebaum, Mark A., Lastra, Ricardo R., Yamada, S.Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019406/
https://www.ncbi.nlm.nih.gov/pubmed/30014022
http://dx.doi.org/10.1016/j.gore.2018.06.008
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author Cowan, Matthew
Suntum, Tara
Olivas, Andrea D.
Perpich, Melody
Applebaum, Mark A.
Lastra, Ricardo R.
Yamada, S.Diane
author_facet Cowan, Matthew
Suntum, Tara
Olivas, Andrea D.
Perpich, Melody
Applebaum, Mark A.
Lastra, Ricardo R.
Yamada, S.Diane
author_sort Cowan, Matthew
collection PubMed
description • Embryonal rhabdomyosarcoma of the uterine cervix and ovarian Sertoli-Leydig cell tumors are associated with DICER1 mutation; • DICER1-associated tumors should prompt genetic counseling and testing; • Somatic and germline genetic mutation profiles can be used to differentiate second primary from recurrent tumors.
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spelling pubmed-60194062018-07-16 Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome Cowan, Matthew Suntum, Tara Olivas, Andrea D. Perpich, Melody Applebaum, Mark A. Lastra, Ricardo R. Yamada, S.Diane Gynecol Oncol Rep Case Report • Embryonal rhabdomyosarcoma of the uterine cervix and ovarian Sertoli-Leydig cell tumors are associated with DICER1 mutation; • DICER1-associated tumors should prompt genetic counseling and testing; • Somatic and germline genetic mutation profiles can be used to differentiate second primary from recurrent tumors. Elsevier 2018-06-15 /pmc/articles/PMC6019406/ /pubmed/30014022 http://dx.doi.org/10.1016/j.gore.2018.06.008 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Cowan, Matthew
Suntum, Tara
Olivas, Andrea D.
Perpich, Melody
Applebaum, Mark A.
Lastra, Ricardo R.
Yamada, S.Diane
Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome
title Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome
title_full Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome
title_fullStr Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome
title_full_unstemmed Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome
title_short Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome
title_sort second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian sertoli-leydig cell tumor: an illustrative case of dicer1 syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019406/
https://www.ncbi.nlm.nih.gov/pubmed/30014022
http://dx.doi.org/10.1016/j.gore.2018.06.008
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