Molecular Regulation of Histamine Synthesis

Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl gr...

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Detalles Bibliográficos
Autores principales: Huang, Hua, Li, Yapeng, Liang, Jinyi, Finkelman, Fred D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019440/
https://www.ncbi.nlm.nih.gov/pubmed/29973935
http://dx.doi.org/10.3389/fimmu.2018.01392
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author Huang, Hua
Li, Yapeng
Liang, Jinyi
Finkelman, Fred D.
author_facet Huang, Hua
Li, Yapeng
Liang, Jinyi
Finkelman, Fred D.
author_sort Huang, Hua
collection PubMed
description Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.
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spelling pubmed-60194402018-07-04 Molecular Regulation of Histamine Synthesis Huang, Hua Li, Yapeng Liang, Jinyi Finkelman, Fred D. Front Immunol Immunology Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis. Frontiers Media S.A. 2018-06-20 /pmc/articles/PMC6019440/ /pubmed/29973935 http://dx.doi.org/10.3389/fimmu.2018.01392 Text en Copyright © 2018 Huang, Li, Liang and Finkelman. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Hua
Li, Yapeng
Liang, Jinyi
Finkelman, Fred D.
Molecular Regulation of Histamine Synthesis
title Molecular Regulation of Histamine Synthesis
title_full Molecular Regulation of Histamine Synthesis
title_fullStr Molecular Regulation of Histamine Synthesis
title_full_unstemmed Molecular Regulation of Histamine Synthesis
title_short Molecular Regulation of Histamine Synthesis
title_sort molecular regulation of histamine synthesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019440/
https://www.ncbi.nlm.nih.gov/pubmed/29973935
http://dx.doi.org/10.3389/fimmu.2018.01392
work_keys_str_mv AT huanghua molecularregulationofhistaminesynthesis
AT liyapeng molecularregulationofhistaminesynthesis
AT liangjinyi molecularregulationofhistaminesynthesis
AT finkelmanfredd molecularregulationofhistaminesynthesis

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