18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK–TRAF6 Interactions and NF-κB and MAPK Signaling Pathways

Bone metabolism is determined by a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts. The imbalance due to over-activated osteoclasts plays an important role in various diseases. Activation of NF-κB and MAPK signaling pathways by receptor activator of nuclear...

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Detalles Bibliográficos
Autores principales: Chen, Xiao, Zhi, Xin, Yin, Zhifeng, Li, Xiaoqun, Qin, Longjuan, Qiu, Zili, Su, Jiacan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019442/
https://www.ncbi.nlm.nih.gov/pubmed/29973878
http://dx.doi.org/10.3389/fphar.2018.00647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019442/
https://www.ncbi.nlm.nih.gov/pubmed/29973878
http://dx.doi.org/10.3389/fphar.2018.00647

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