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Synthetic Standards Combined With Error and Bias Correction Improve the Accuracy and Quantitative Resolution of Antibody Repertoire Sequencing in Human Naïve and Memory B Cells

High-throughput sequencing of immunoglobulin (Ig) repertoires (Ig-seq) is a powerful method for quantitatively interrogating B cell receptor sequence diversity. When applied to human repertoires, Ig-seq provides insight into fundamental immunological questions, and can be implemented in diagnostic a...

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Detalles Bibliográficos
Autores principales:	Friedensohn, Simon, Lindner, John M., Cornacchione, Vanessa, Iazeolla, Mariavittoria, Miho, Enkelejda, Zingg, Andreas, Meng, Simon, Traggiai, Elisabetta, Reddy, Sai T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019461/ https://www.ncbi.nlm.nih.gov/pubmed/29973938 http://dx.doi.org/10.3389/fimmu.2018.01401

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