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The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury
Skeletal muscle is prone to damage from a range of stimuli, and initiates a robust repair process that requires the participation of immune cells. Among the more well characterized immune cells involved in muscle repair are those of the myeloid lineage, including neutrophils, macrophages, monocytes,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019499/ https://www.ncbi.nlm.nih.gov/pubmed/29973887 http://dx.doi.org/10.3389/fphys.2018.00768 |
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author | Deyhle, Michael R. Hyldahl, Robert D. |
author_facet | Deyhle, Michael R. Hyldahl, Robert D. |
author_sort | Deyhle, Michael R. |
collection | PubMed |
description | Skeletal muscle is prone to damage from a range of stimuli, and initiates a robust repair process that requires the participation of immune cells. Among the more well characterized immune cells involved in muscle repair are those of the myeloid lineage, including neutrophils, macrophages, monocytes, and eosinophils. More recently, studies have begun to elucidate the role of the lymphoid-derived immune cells, most notably T lymphocytes (T-cells), in the complex processes of muscle repair. Though T-cells have been traditionally been associated with pathological degeneration of skeletal muscle in disease, recent studies show that T-cells are instrumental in the repair/regeneration process following severe muscle damage in mice. Furthermore, a few studies using basic immunohistochemical assays have shown that T-cells accumulate in human skeletal muscle in the days following contraction-induced muscle damage. The functional significance of T-cells in the repair and adaptation process following contraction-induce muscle damage remains uncertain, and is an active area of intense investigation. This mini-review summarizes recent findings on the involvement of T-cells in skeletal muscle repair. |
format | Online Article Text |
id | pubmed-6019499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60194992018-07-04 The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury Deyhle, Michael R. Hyldahl, Robert D. Front Physiol Physiology Skeletal muscle is prone to damage from a range of stimuli, and initiates a robust repair process that requires the participation of immune cells. Among the more well characterized immune cells involved in muscle repair are those of the myeloid lineage, including neutrophils, macrophages, monocytes, and eosinophils. More recently, studies have begun to elucidate the role of the lymphoid-derived immune cells, most notably T lymphocytes (T-cells), in the complex processes of muscle repair. Though T-cells have been traditionally been associated with pathological degeneration of skeletal muscle in disease, recent studies show that T-cells are instrumental in the repair/regeneration process following severe muscle damage in mice. Furthermore, a few studies using basic immunohistochemical assays have shown that T-cells accumulate in human skeletal muscle in the days following contraction-induced muscle damage. The functional significance of T-cells in the repair and adaptation process following contraction-induce muscle damage remains uncertain, and is an active area of intense investigation. This mini-review summarizes recent findings on the involvement of T-cells in skeletal muscle repair. Frontiers Media S.A. 2018-06-20 /pmc/articles/PMC6019499/ /pubmed/29973887 http://dx.doi.org/10.3389/fphys.2018.00768 Text en Copyright © 2018 Deyhle and Hyldahl. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Deyhle, Michael R. Hyldahl, Robert D. The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury |
title | The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury |
title_full | The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury |
title_fullStr | The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury |
title_full_unstemmed | The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury |
title_short | The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury |
title_sort | role of t lymphocytes in skeletal muscle repair from traumatic and contraction-induced injury |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019499/ https://www.ncbi.nlm.nih.gov/pubmed/29973887 http://dx.doi.org/10.3389/fphys.2018.00768 |
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