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Otitis in a cat associated with Corynebacterium provencense

BACKGROUND: The role of corynebacteria in canine and feline otitis has not been investigated in detail; however, members of this genus are increasingly recognized as pathogens of otitis in both human and veterinary medicine. CASE PRESENTATION: Here we report the first case of feline otitis associate...

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Autores principales: Kittl, Sonja, Brodard, Isabelle, Rychener, Lorenz, Jores, Jörg, Roosje, Petra, Gobeli Brawand, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019829/
https://www.ncbi.nlm.nih.gov/pubmed/29940943
http://dx.doi.org/10.1186/s12917-018-1526-9
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author Kittl, Sonja
Brodard, Isabelle
Rychener, Lorenz
Jores, Jörg
Roosje, Petra
Gobeli Brawand, Stefanie
author_facet Kittl, Sonja
Brodard, Isabelle
Rychener, Lorenz
Jores, Jörg
Roosje, Petra
Gobeli Brawand, Stefanie
author_sort Kittl, Sonja
collection PubMed
description BACKGROUND: The role of corynebacteria in canine and feline otitis has not been investigated in detail; however, members of this genus are increasingly recognized as pathogens of otitis in both human and veterinary medicine. CASE PRESENTATION: Here we report the first case of feline otitis associated with the recently described species Corynebacterium provencense. A seven-month old cat presented with a head tilt and ataxia was diagnosed with peripheral vestibular syndrome associated with an otitis media/interna. This took place 6 weeks after resection of a polyp, having initially shown a full recovery with topical ofloxacin and glucocorticoid treatment. Bacteriology of an ear swab yielded a pure culture of corynebacteria, which could not be identified at the species level using routine methods. However, the 16S rRNA gene sequence was 100% identical to the recently published novel corynebacterium species, Corynebacterium provencense. Whole genome sequencing of the cat isolate and calculation of average nucleotide identity (99.1%) confirmed this finding. The cat isolate was found to contain additional presumptive iron acquisition genes that are likely to encode virulence factors. Furthermore, the strain tested resistant to clindamycin, penicillin and ciprofloxacin. The cat was subsequently treated with chloramphenicol, which lead to clinical improvement. CONCLUSION: Corynebacteria from otitis cases are not routinely identified at the species level and not tested for antimicrobial susceptibility in veterinary laboratories, as they are not considered major pathogens. This may lead to underreporting of this genus or animals being treated with inappropriate antimicrobials since corynebacteria are often resistant to multiple drugs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-018-1526-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-60198292018-07-06 Otitis in a cat associated with Corynebacterium provencense Kittl, Sonja Brodard, Isabelle Rychener, Lorenz Jores, Jörg Roosje, Petra Gobeli Brawand, Stefanie BMC Vet Res Case Report BACKGROUND: The role of corynebacteria in canine and feline otitis has not been investigated in detail; however, members of this genus are increasingly recognized as pathogens of otitis in both human and veterinary medicine. CASE PRESENTATION: Here we report the first case of feline otitis associated with the recently described species Corynebacterium provencense. A seven-month old cat presented with a head tilt and ataxia was diagnosed with peripheral vestibular syndrome associated with an otitis media/interna. This took place 6 weeks after resection of a polyp, having initially shown a full recovery with topical ofloxacin and glucocorticoid treatment. Bacteriology of an ear swab yielded a pure culture of corynebacteria, which could not be identified at the species level using routine methods. However, the 16S rRNA gene sequence was 100% identical to the recently published novel corynebacterium species, Corynebacterium provencense. Whole genome sequencing of the cat isolate and calculation of average nucleotide identity (99.1%) confirmed this finding. The cat isolate was found to contain additional presumptive iron acquisition genes that are likely to encode virulence factors. Furthermore, the strain tested resistant to clindamycin, penicillin and ciprofloxacin. The cat was subsequently treated with chloramphenicol, which lead to clinical improvement. CONCLUSION: Corynebacteria from otitis cases are not routinely identified at the species level and not tested for antimicrobial susceptibility in veterinary laboratories, as they are not considered major pathogens. This may lead to underreporting of this genus or animals being treated with inappropriate antimicrobials since corynebacteria are often resistant to multiple drugs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-018-1526-9) contains supplementary material, which is available to authorized users. BioMed Central 2018-06-25 /pmc/articles/PMC6019829/ /pubmed/29940943 http://dx.doi.org/10.1186/s12917-018-1526-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kittl, Sonja
Brodard, Isabelle
Rychener, Lorenz
Jores, Jörg
Roosje, Petra
Gobeli Brawand, Stefanie
Otitis in a cat associated with Corynebacterium provencense
title Otitis in a cat associated with Corynebacterium provencense
title_full Otitis in a cat associated with Corynebacterium provencense
title_fullStr Otitis in a cat associated with Corynebacterium provencense
title_full_unstemmed Otitis in a cat associated with Corynebacterium provencense
title_short Otitis in a cat associated with Corynebacterium provencense
title_sort otitis in a cat associated with corynebacterium provencense
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019829/
https://www.ncbi.nlm.nih.gov/pubmed/29940943
http://dx.doi.org/10.1186/s12917-018-1526-9
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