Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun

Osteosarcoma is a mesenchymally derived, high-grade bone sarcoma that is the most frequently diagnosed primary malignant bone tumor. Today, chemoprevention is regarded as a promising and realistic approach in the prevention of human cancer. Previous studies have suggested ellagic acid (EA) and Senno...

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Autores principales: Xu, Wei, Xu, Jinjin, Wang, Ting, Liu, Weibo, Wei, Haifeng, Yang, Xinghai, Yan, Wangjun, Zhou, Wang, Xiao, Jianru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019914/
https://www.ncbi.nlm.nih.gov/pubmed/29963161
http://dx.doi.org/10.3892/ol.2018.8712
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author Xu, Wei
Xu, Jinjin
Wang, Ting
Liu, Weibo
Wei, Haifeng
Yang, Xinghai
Yan, Wangjun
Zhou, Wang
Xiao, Jianru
author_facet Xu, Wei
Xu, Jinjin
Wang, Ting
Liu, Weibo
Wei, Haifeng
Yang, Xinghai
Yan, Wangjun
Zhou, Wang
Xiao, Jianru
author_sort Xu, Wei
collection PubMed
description Osteosarcoma is a mesenchymally derived, high-grade bone sarcoma that is the most frequently diagnosed primary malignant bone tumor. Today, chemoprevention is regarded as a promising and realistic approach in the prevention of human cancer. Previous studies have suggested ellagic acid (EA) and Sennoside B have potential in this regard. The aim of the present study was to elucidate the anti-osteosarcoma effects of EA and Sennoside B by using Saos-2 and MG63 osteosarcoma cells. It was identified that EA or Sennoside B treatment could inhibit the growth, migration and invasion of the cells, and induce G(1) cell cycle arrest by repressing the transcription of c-Jun. These results may provide a cellular basis for the application of EA or Sennoside B in the treatment of patients with osteosarcoma.
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spelling pubmed-60199142018-06-29 Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun Xu, Wei Xu, Jinjin Wang, Ting Liu, Weibo Wei, Haifeng Yang, Xinghai Yan, Wangjun Zhou, Wang Xiao, Jianru Oncol Lett Articles Osteosarcoma is a mesenchymally derived, high-grade bone sarcoma that is the most frequently diagnosed primary malignant bone tumor. Today, chemoprevention is regarded as a promising and realistic approach in the prevention of human cancer. Previous studies have suggested ellagic acid (EA) and Sennoside B have potential in this regard. The aim of the present study was to elucidate the anti-osteosarcoma effects of EA and Sennoside B by using Saos-2 and MG63 osteosarcoma cells. It was identified that EA or Sennoside B treatment could inhibit the growth, migration and invasion of the cells, and induce G(1) cell cycle arrest by repressing the transcription of c-Jun. These results may provide a cellular basis for the application of EA or Sennoside B in the treatment of patients with osteosarcoma. D.A. Spandidos 2018-07 2018-05-16 /pmc/articles/PMC6019914/ /pubmed/29963161 http://dx.doi.org/10.3892/ol.2018.8712 Text en Copyright: © Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Xu, Wei
Xu, Jinjin
Wang, Ting
Liu, Weibo
Wei, Haifeng
Yang, Xinghai
Yan, Wangjun
Zhou, Wang
Xiao, Jianru
Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun
title Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun
title_full Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun
title_fullStr Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun
title_full_unstemmed Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun
title_short Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun
title_sort ellagic acid and sennoside b inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-jun
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019914/
https://www.ncbi.nlm.nih.gov/pubmed/29963161
http://dx.doi.org/10.3892/ol.2018.8712
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