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Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis

Liposarcoma is the most common type of soft-tissue sarcoma, and predominantly originates from the extremities and retroperitoneal cavity. However, primary endobronchial liposarcoma is extremely rare. The present study reports on the case of a 54-year-old man, a smoker, diagnosed with primary endobro...

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Autores principales: Liu, Yuanshun, Jiang, Hua, Xu, Qiuran, Zhou, Hongbin, Li, Yaqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019946/
https://www.ncbi.nlm.nih.gov/pubmed/29963153
http://dx.doi.org/10.3892/ol.2018.8737
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author Liu, Yuanshun
Jiang, Hua
Xu, Qiuran
Zhou, Hongbin
Li, Yaqing
author_facet Liu, Yuanshun
Jiang, Hua
Xu, Qiuran
Zhou, Hongbin
Li, Yaqing
author_sort Liu, Yuanshun
collection PubMed
description Liposarcoma is the most common type of soft-tissue sarcoma, and predominantly originates from the extremities and retroperitoneal cavity. However, primary endobronchial liposarcoma is extremely rare. The present study reports on the case of a 54-year-old man, a smoker, diagnosed with primary endobronchial atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLS), which was successfully resected via bronchoscopy. Chest computed tomography (CT) revealed a neoplasm in the left main bronchus measuring 12.8×7.8 mm. Bronchoscopy demonstrated multiple roundish, pedunculated, polypoid masses in the left main bronchus. Bioptic specimens were obtained from the roundish masses, and pathological examination revealed an adipose tissue-derived tumor. The masses were completely resected during the second bronchoscopy under general anesthesia. Histopathological examination of the radical resection specimen revealed that it was an ALT-WDLS. The patient showed good quality of life at the 6-month postoperative follow-up without evidence of recurrence. Immunohistochemistry was completed with the human homologue of murine double-minute type 2 (MDM2) (+), cyclin-dependent kinase 4 (CDK4) (+), p16 (+), S-100 (+), Ki-67 (+), cluster of differentiation 34 (CD34) (+) and retinoblastoma protein (+), confirming ALT-WDLS. However, the fluorescence in situ hybridization assay revealed no amplification of MDM2 and CDK4 in the ALT-WDLS. To the best of our knowledge, the present case report is the first to describe the clinicopathologic features and genetic analysis of endobronchial liposarcoma. Although rare, this case is a reminder that clinicians should consider the possibility of this rare endobronchial tumor in patients with nonspecific symptoms including chronic cough, chest pain and recurrent pneumonia. As in this case, endoscopic treatment provided an excellent clinical outcome in patients with primary endobronchial ALT-WDLS.
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spelling pubmed-60199462018-06-29 Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis Liu, Yuanshun Jiang, Hua Xu, Qiuran Zhou, Hongbin Li, Yaqing Oncol Lett Articles Liposarcoma is the most common type of soft-tissue sarcoma, and predominantly originates from the extremities and retroperitoneal cavity. However, primary endobronchial liposarcoma is extremely rare. The present study reports on the case of a 54-year-old man, a smoker, diagnosed with primary endobronchial atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLS), which was successfully resected via bronchoscopy. Chest computed tomography (CT) revealed a neoplasm in the left main bronchus measuring 12.8×7.8 mm. Bronchoscopy demonstrated multiple roundish, pedunculated, polypoid masses in the left main bronchus. Bioptic specimens were obtained from the roundish masses, and pathological examination revealed an adipose tissue-derived tumor. The masses were completely resected during the second bronchoscopy under general anesthesia. Histopathological examination of the radical resection specimen revealed that it was an ALT-WDLS. The patient showed good quality of life at the 6-month postoperative follow-up without evidence of recurrence. Immunohistochemistry was completed with the human homologue of murine double-minute type 2 (MDM2) (+), cyclin-dependent kinase 4 (CDK4) (+), p16 (+), S-100 (+), Ki-67 (+), cluster of differentiation 34 (CD34) (+) and retinoblastoma protein (+), confirming ALT-WDLS. However, the fluorescence in situ hybridization assay revealed no amplification of MDM2 and CDK4 in the ALT-WDLS. To the best of our knowledge, the present case report is the first to describe the clinicopathologic features and genetic analysis of endobronchial liposarcoma. Although rare, this case is a reminder that clinicians should consider the possibility of this rare endobronchial tumor in patients with nonspecific symptoms including chronic cough, chest pain and recurrent pneumonia. As in this case, endoscopic treatment provided an excellent clinical outcome in patients with primary endobronchial ALT-WDLS. D.A. Spandidos 2018-07 2018-05-18 /pmc/articles/PMC6019946/ /pubmed/29963153 http://dx.doi.org/10.3892/ol.2018.8737 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Liu, Yuanshun
Jiang, Hua
Xu, Qiuran
Zhou, Hongbin
Li, Yaqing
Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis
title Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis
title_full Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis
title_fullStr Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis
title_full_unstemmed Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis
title_short Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis
title_sort primary endobronchial liposarcoma successfully resected via bronchoscopy: a rare case report with genetic analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019946/
https://www.ncbi.nlm.nih.gov/pubmed/29963153
http://dx.doi.org/10.3892/ol.2018.8737
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