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Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Hepatocellular carcinoma (HCC) is highly refractory to current therapeutics used in the clinic. DX-2647, a recombinant human antibody, potently neutralizes the action of insulin-like growth factor-II (IGF-II), a ligand for three cell-surface receptors (IGF-IR, insulin receptor A and B isoforms, and...

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Detalles Bibliográficos
Autores principales:	Greenall, Sameer A., Donoghue, Jacqueline, Johns, Terrance G., Adams, Timothy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2018
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020079/ https://www.ncbi.nlm.nih.gov/pubmed/29933129 http://dx.doi.org/10.1016/j.tranon.2018.05.011

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