Cargando…
Anal gland adenocarcinoma in situ with pagetoid spread: a case report
BACKGROUND: Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. CASE PRESENTATION: Physical examination in a 75-year-old woman revealed an erythema...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020090/ https://www.ncbi.nlm.nih.gov/pubmed/29943205 http://dx.doi.org/10.1186/s40792-018-0469-5 |
_version_ | 1783335229139714048 |
---|---|
author | Ishioka, Kohei Koyama, Fumikazu Kuge, Hiroyuki Inoue, Takashi Obara, Shinsaku Nakamoto, Takayuki Sasaki, Yoshiyuki Nakamura, Yasuyuki Takeda, Maiko Ohbayashi, Chiho Kuwahara, Masamitsu Sho, Masayuki |
author_facet | Ishioka, Kohei Koyama, Fumikazu Kuge, Hiroyuki Inoue, Takashi Obara, Shinsaku Nakamoto, Takayuki Sasaki, Yoshiyuki Nakamura, Yasuyuki Takeda, Maiko Ohbayashi, Chiho Kuwahara, Masamitsu Sho, Masayuki |
author_sort | Ishioka, Kohei |
collection | PubMed |
description | BACKGROUND: Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. CASE PRESENTATION: Physical examination in a 75-year-old woman revealed an erythematous, inflamed, perianal skin lesion. Neither colposcopy, cystoscopy, colonoscopy, computed tomography, nor magnetic resonance imaging showed evidence of malignant genitourinary or gastrointestinal lesions. Histopathological examination of a biopsy specimen showed many Paget’s cells in the perianal skin lesion and no malignant cells in the rectal or vaginal mucosa. Therefore, primary extramammary Paget’s disease of the anogenital region was suspected, and we performed anus-preserving wide local excision. However, immunohistochemistry revealed a diagnosis of secondary extramammary Paget’s disease due to adenocarcinoma arising from the anal gland. We therefore proceeded with a radical operation. Histopathological examination showed no residual cancer cells. The final diagnosis was anal gland adenocarcinoma in situ with pagetoid spread in the perianal skin. CONCLUSIONS: This is the first case report of anal gland adenocarcinoma in situ with pagetoid spread. We recommend immunohistochemical analysis of biopsy and locally resected specimens to obtain an accurate diagnosis and determine the appropriate treatment when there is no visible tumor. |
format | Online Article Text |
id | pubmed-6020090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-60200902018-07-13 Anal gland adenocarcinoma in situ with pagetoid spread: a case report Ishioka, Kohei Koyama, Fumikazu Kuge, Hiroyuki Inoue, Takashi Obara, Shinsaku Nakamoto, Takayuki Sasaki, Yoshiyuki Nakamura, Yasuyuki Takeda, Maiko Ohbayashi, Chiho Kuwahara, Masamitsu Sho, Masayuki Surg Case Rep Case Report BACKGROUND: Anal gland carcinoma with perianal Paget’s disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. CASE PRESENTATION: Physical examination in a 75-year-old woman revealed an erythematous, inflamed, perianal skin lesion. Neither colposcopy, cystoscopy, colonoscopy, computed tomography, nor magnetic resonance imaging showed evidence of malignant genitourinary or gastrointestinal lesions. Histopathological examination of a biopsy specimen showed many Paget’s cells in the perianal skin lesion and no malignant cells in the rectal or vaginal mucosa. Therefore, primary extramammary Paget’s disease of the anogenital region was suspected, and we performed anus-preserving wide local excision. However, immunohistochemistry revealed a diagnosis of secondary extramammary Paget’s disease due to adenocarcinoma arising from the anal gland. We therefore proceeded with a radical operation. Histopathological examination showed no residual cancer cells. The final diagnosis was anal gland adenocarcinoma in situ with pagetoid spread in the perianal skin. CONCLUSIONS: This is the first case report of anal gland adenocarcinoma in situ with pagetoid spread. We recommend immunohistochemical analysis of biopsy and locally resected specimens to obtain an accurate diagnosis and determine the appropriate treatment when there is no visible tumor. Springer Berlin Heidelberg 2018-06-25 /pmc/articles/PMC6020090/ /pubmed/29943205 http://dx.doi.org/10.1186/s40792-018-0469-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Ishioka, Kohei Koyama, Fumikazu Kuge, Hiroyuki Inoue, Takashi Obara, Shinsaku Nakamoto, Takayuki Sasaki, Yoshiyuki Nakamura, Yasuyuki Takeda, Maiko Ohbayashi, Chiho Kuwahara, Masamitsu Sho, Masayuki Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
title | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
title_full | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
title_fullStr | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
title_full_unstemmed | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
title_short | Anal gland adenocarcinoma in situ with pagetoid spread: a case report |
title_sort | anal gland adenocarcinoma in situ with pagetoid spread: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020090/ https://www.ncbi.nlm.nih.gov/pubmed/29943205 http://dx.doi.org/10.1186/s40792-018-0469-5 |
work_keys_str_mv | AT ishiokakohei analglandadenocarcinomainsituwithpagetoidspreadacasereport AT koyamafumikazu analglandadenocarcinomainsituwithpagetoidspreadacasereport AT kugehiroyuki analglandadenocarcinomainsituwithpagetoidspreadacasereport AT inouetakashi analglandadenocarcinomainsituwithpagetoidspreadacasereport AT obarashinsaku analglandadenocarcinomainsituwithpagetoidspreadacasereport AT nakamototakayuki analglandadenocarcinomainsituwithpagetoidspreadacasereport AT sasakiyoshiyuki analglandadenocarcinomainsituwithpagetoidspreadacasereport AT nakamurayasuyuki analglandadenocarcinomainsituwithpagetoidspreadacasereport AT takedamaiko analglandadenocarcinomainsituwithpagetoidspreadacasereport AT ohbayashichiho analglandadenocarcinomainsituwithpagetoidspreadacasereport AT kuwaharamasamitsu analglandadenocarcinomainsituwithpagetoidspreadacasereport AT shomasayuki analglandadenocarcinomainsituwithpagetoidspreadacasereport |