Parkinson’s disease-associated protein Parkin: an unusual player in cancer

The mutation of the Parkin gene is a cause of familial Parkinson’s disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell...

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Detalles Bibliográficos
Autores principales: Liu, Juan, Zhang, Cen, Hu, Wenwei, Feng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020249/
https://www.ncbi.nlm.nih.gov/pubmed/29941042
http://dx.doi.org/10.1186/s40880-018-0314-z
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author Liu, Juan
Zhang, Cen
Hu, Wenwei
Feng, Zhaohui
author_facet Liu, Juan
Zhang, Cen
Hu, Wenwei
Feng, Zhaohui
author_sort Liu, Juan
collection PubMed
description The mutation of the Parkin gene is a cause of familial Parkinson’s disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.
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spelling pubmed-60202492018-07-06 Parkinson’s disease-associated protein Parkin: an unusual player in cancer Liu, Juan Zhang, Cen Hu, Wenwei Feng, Zhaohui Cancer Commun (Lond) Review The mutation of the Parkin gene is a cause of familial Parkinson’s disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer. BioMed Central 2018-06-26 /pmc/articles/PMC6020249/ /pubmed/29941042 http://dx.doi.org/10.1186/s40880-018-0314-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Liu, Juan
Zhang, Cen
Hu, Wenwei
Feng, Zhaohui
Parkinson’s disease-associated protein Parkin: an unusual player in cancer
title Parkinson’s disease-associated protein Parkin: an unusual player in cancer
title_full Parkinson’s disease-associated protein Parkin: an unusual player in cancer
title_fullStr Parkinson’s disease-associated protein Parkin: an unusual player in cancer
title_full_unstemmed Parkinson’s disease-associated protein Parkin: an unusual player in cancer
title_short Parkinson’s disease-associated protein Parkin: an unusual player in cancer
title_sort parkinson’s disease-associated protein parkin: an unusual player in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020249/
https://www.ncbi.nlm.nih.gov/pubmed/29941042
http://dx.doi.org/10.1186/s40880-018-0314-z
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