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Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations

BACKGROUND: DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome methylation and targeted mutation analysis of colorectal cancer (CRC)-related gen...

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Detalles Bibliográficos
Autores principales:	Molnár, Béla, Galamb, Orsolya, Péterfia, Bálint, Wichmann, Barnabás, Csabai, István, Bodor, András, Kalmár, Alexandra, Szigeti, Krisztina Andrea, Barták, Barbara Kinga, Nagy, Zsófia Brigitta, Valcz, Gábor, Patai, Árpád V., Igaz, Péter, Tulassay, Zsolt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020382/ https://www.ncbi.nlm.nih.gov/pubmed/29945573 http://dx.doi.org/10.1186/s12885-018-4609-x

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