iPSC-derived familial Alzheimer’s PSEN2(N141I) cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling

BACKGROUND: Type 2 diabetes (T2D) is a recognized risk factor for the development of cognitive impairment (CI) and/or dementia, although the exact nature of the molecular pathology of T2D-associated CI remains obscure. One link between T2D and CI might involve decreased insulin signaling in brain an...

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Detalles Bibliográficos
Autores principales: Moreno, Cesar L., Guardia, Lucio Della, Shnyder, Valeria, Ortiz-Virumbrales, Maitane, Kruglikov, Ilya, Zhang, Bin, Schadt, Eric E., Tanzi, Rudolph E., Noggle, Scott, Buettner, Christoph, Gandy, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020427/
https://www.ncbi.nlm.nih.gov/pubmed/29945658
http://dx.doi.org/10.1186/s13024-018-0265-5

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