Cargando…

Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children

INTRODUCTION: Obesity is a worldwide concern. It is associated with morbidity such as dyslipidemia and liver disease. Childhood obesity has dramatically increased, particularly in the Gulf region. We aim to assess the prevalence of dyslipidemia and fatty liver disease (FLD) in overweight and obese c...

Descripción completa

Detalles Bibliográficos
Autores principales: Deeb, Asma, Attia, Salima, Mahmoud, Samia, Elhaj, Ghada, Elfatih, Abubaker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020453/
https://www.ncbi.nlm.nih.gov/pubmed/30009050
http://dx.doi.org/10.1155/2018/8626818
_version_ 1783335298240872448
author Deeb, Asma
Attia, Salima
Mahmoud, Samia
Elhaj, Ghada
Elfatih, Abubaker
author_facet Deeb, Asma
Attia, Salima
Mahmoud, Samia
Elhaj, Ghada
Elfatih, Abubaker
author_sort Deeb, Asma
collection PubMed
description INTRODUCTION: Obesity is a worldwide concern. It is associated with morbidity such as dyslipidemia and liver disease. Childhood obesity has dramatically increased, particularly in the Gulf region. We aim to assess the prevalence of dyslipidemia and fatty liver disease (FLD) in overweight and obese children and analyze the association between different anthropometric measures with dyslipidemia and fatty liver disease. METHODS: A descriptive, cross-sectional study conducted on children referred with obesity. BMI percentiles were plotted and standardized waist circumference (WC) was generated. Family history of metabolic syndrome was recorded. Fasting lipid, liver transaminases, and ultrasound scans (US) for those with elevated enzymes were performed. Descriptive statistics were used for quantitative parameters. RESULTS: 216 participants were recruited. Mean ± SD age was 10.58 ± 2.996 years. 55.3% had dyslipidemia; 11.7% had high cholesterol, 28.6% high triglyceride, 32.7% high LDL, and 18.0% low HDL. 51 (84%) had either elevated transaminases. All had liver US, and 43 had FLD. WC was strongly associated with dyslipidemia and FLD (P=0.04  and  0.003). CONCLUSION: Dyslipidemia is common in overweight, obese children. FLD is prevalent in those with elevated liver transaminases. WC is an easy tool that can be utilized to screen for dyslipidemia and FLD in overweight and obese children.
format Online
Article
Text
id pubmed-6020453
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-60204532018-07-15 Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children Deeb, Asma Attia, Salima Mahmoud, Samia Elhaj, Ghada Elfatih, Abubaker J Obes Research Article INTRODUCTION: Obesity is a worldwide concern. It is associated with morbidity such as dyslipidemia and liver disease. Childhood obesity has dramatically increased, particularly in the Gulf region. We aim to assess the prevalence of dyslipidemia and fatty liver disease (FLD) in overweight and obese children and analyze the association between different anthropometric measures with dyslipidemia and fatty liver disease. METHODS: A descriptive, cross-sectional study conducted on children referred with obesity. BMI percentiles were plotted and standardized waist circumference (WC) was generated. Family history of metabolic syndrome was recorded. Fasting lipid, liver transaminases, and ultrasound scans (US) for those with elevated enzymes were performed. Descriptive statistics were used for quantitative parameters. RESULTS: 216 participants were recruited. Mean ± SD age was 10.58 ± 2.996 years. 55.3% had dyslipidemia; 11.7% had high cholesterol, 28.6% high triglyceride, 32.7% high LDL, and 18.0% low HDL. 51 (84%) had either elevated transaminases. All had liver US, and 43 had FLD. WC was strongly associated with dyslipidemia and FLD (P=0.04  and  0.003). CONCLUSION: Dyslipidemia is common in overweight, obese children. FLD is prevalent in those with elevated liver transaminases. WC is an easy tool that can be utilized to screen for dyslipidemia and FLD in overweight and obese children. Hindawi 2018-06-12 /pmc/articles/PMC6020453/ /pubmed/30009050 http://dx.doi.org/10.1155/2018/8626818 Text en Copyright © 2018 Asma Deeb et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Deeb, Asma
Attia, Salima
Mahmoud, Samia
Elhaj, Ghada
Elfatih, Abubaker
Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children
title Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children
title_full Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children
title_fullStr Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children
title_full_unstemmed Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children
title_short Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children
title_sort dyslipidemia and fatty liver disease in overweight and obese children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020453/
https://www.ncbi.nlm.nih.gov/pubmed/30009050
http://dx.doi.org/10.1155/2018/8626818
work_keys_str_mv AT deebasma dyslipidemiaandfattyliverdiseaseinoverweightandobesechildren
AT attiasalima dyslipidemiaandfattyliverdiseaseinoverweightandobesechildren
AT mahmoudsamia dyslipidemiaandfattyliverdiseaseinoverweightandobesechildren
AT elhajghada dyslipidemiaandfattyliverdiseaseinoverweightandobesechildren
AT elfatihabubaker dyslipidemiaandfattyliverdiseaseinoverweightandobesechildren