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Potential of Gene and Cell Therapy for Inner Ear Hair Cells

Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are availa...

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Autores principales: Lee, Min Yong, Park, Yong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020521/
https://www.ncbi.nlm.nih.gov/pubmed/30009175
http://dx.doi.org/10.1155/2018/8137614
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author Lee, Min Yong
Park, Yong-Ho
author_facet Lee, Min Yong
Park, Yong-Ho
author_sort Lee, Min Yong
collection PubMed
description Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the “naïve” cochlea. Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss. Cochlear HC regeneration has long been an important goal in the field of hearing research. However, it remains challenging because, thus far, no medical treatment has successfully regenerated cochlear HCs. Recent advances in genetic modulation and developmental techniques have led to novel approaches to generating HCs or protecting against HC loss, to preserve hearing. In this review, we present and review the current status of two different approaches to restoring or protecting hearing, gene therapy, including the newly introduced CRISPR/Cas9 genome editing, and stem cell therapy, and suggest the future direction.
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spelling pubmed-60205212018-07-15 Potential of Gene and Cell Therapy for Inner Ear Hair Cells Lee, Min Yong Park, Yong-Ho Biomed Res Int Review Article Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the “naïve” cochlea. Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss. Cochlear HC regeneration has long been an important goal in the field of hearing research. However, it remains challenging because, thus far, no medical treatment has successfully regenerated cochlear HCs. Recent advances in genetic modulation and developmental techniques have led to novel approaches to generating HCs or protecting against HC loss, to preserve hearing. In this review, we present and review the current status of two different approaches to restoring or protecting hearing, gene therapy, including the newly introduced CRISPR/Cas9 genome editing, and stem cell therapy, and suggest the future direction. Hindawi 2018-06-13 /pmc/articles/PMC6020521/ /pubmed/30009175 http://dx.doi.org/10.1155/2018/8137614 Text en Copyright © 2018 Min Yong Lee and Yong-Ho Park. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Min Yong
Park, Yong-Ho
Potential of Gene and Cell Therapy for Inner Ear Hair Cells
title Potential of Gene and Cell Therapy for Inner Ear Hair Cells
title_full Potential of Gene and Cell Therapy for Inner Ear Hair Cells
title_fullStr Potential of Gene and Cell Therapy for Inner Ear Hair Cells
title_full_unstemmed Potential of Gene and Cell Therapy for Inner Ear Hair Cells
title_short Potential of Gene and Cell Therapy for Inner Ear Hair Cells
title_sort potential of gene and cell therapy for inner ear hair cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020521/
https://www.ncbi.nlm.nih.gov/pubmed/30009175
http://dx.doi.org/10.1155/2018/8137614
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