Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate

A previously healthy 10-year-old girl presented to the emergency department (ED) with a headache and vomiting which resolved with oral NSAIDs. The patient returned two days later unable to ambulate with mental slowing and lower extremity bruising. Labs demonstrated marked leukocytosis, severe anemia...

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Detalles Bibliográficos
Autores principales: Schwartz, Kevin R., Hanson, Jennifer M., Friedmann, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020537/
https://www.ncbi.nlm.nih.gov/pubmed/30009060
http://dx.doi.org/10.1155/2018/5241425
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author Schwartz, Kevin R.
Hanson, Jennifer M.
Friedmann, Alison M.
author_facet Schwartz, Kevin R.
Hanson, Jennifer M.
Friedmann, Alison M.
author_sort Schwartz, Kevin R.
collection PubMed
description A previously healthy 10-year-old girl presented to the emergency department (ED) with a headache and vomiting which resolved with oral NSAIDs. The patient returned two days later unable to ambulate with mental slowing and lower extremity bruising. Labs demonstrated marked leukocytosis, severe anemia and thrombocytopenia, and disseminated intravascular coagulation (DIC). Brain MRI showed multiple intracranial hemorrhages. A peripheral blood smear demonstrated blasts with many Auer rods. A diagnosis of acute promyelocytic leukemia (APL) was made and therapy including all-transretinoic acid (ATRA) was initiated. Neurologic status returned to baseline within 1 week in the pediatric intensive care unit.
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spelling pubmed-60205372018-07-15 Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate Schwartz, Kevin R. Hanson, Jennifer M. Friedmann, Alison M. Case Rep Emerg Med Case Report A previously healthy 10-year-old girl presented to the emergency department (ED) with a headache and vomiting which resolved with oral NSAIDs. The patient returned two days later unable to ambulate with mental slowing and lower extremity bruising. Labs demonstrated marked leukocytosis, severe anemia and thrombocytopenia, and disseminated intravascular coagulation (DIC). Brain MRI showed multiple intracranial hemorrhages. A peripheral blood smear demonstrated blasts with many Auer rods. A diagnosis of acute promyelocytic leukemia (APL) was made and therapy including all-transretinoic acid (ATRA) was initiated. Neurologic status returned to baseline within 1 week in the pediatric intensive care unit. Hindawi 2018-06-12 /pmc/articles/PMC6020537/ /pubmed/30009060 http://dx.doi.org/10.1155/2018/5241425 Text en Copyright © 2018 Kevin R. Schwartz et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Schwartz, Kevin R.
Hanson, Jennifer M.
Friedmann, Alison M.
Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate
title Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate
title_full Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate
title_fullStr Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate
title_full_unstemmed Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate
title_short Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate
title_sort pediatric acute promyelocytic leukemia presenting to the emergency department as refusal to ambulate
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020537/
https://www.ncbi.nlm.nih.gov/pubmed/30009060
http://dx.doi.org/10.1155/2018/5241425
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AT friedmannalisonm pediatricacutepromyelocyticleukemiapresentingtotheemergencydepartmentasrefusaltoambulate

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