Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardi...

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Autores principales: Lu, Yapeng, Liu, Rui, Zha, Luting, Yuan, Shan, Tian, Lang, Chen, Jia, Huang, Lihua, Yang, Zuocheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020540/
https://www.ncbi.nlm.nih.gov/pubmed/30008974
http://dx.doi.org/10.1155/2018/1064380
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author Lu, Yapeng
Liu, Rui
Zha, Luting
Yuan, Shan
Tian, Lang
Chen, Jia
Huang, Lihua
Yang, Zuocheng
author_facet Lu, Yapeng
Liu, Rui
Zha, Luting
Yuan, Shan
Tian, Lang
Chen, Jia
Huang, Lihua
Yang, Zuocheng
author_sort Lu, Yapeng
collection PubMed
description Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance.
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spelling pubmed-60205402018-07-15 Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children Lu, Yapeng Liu, Rui Zha, Luting Yuan, Shan Tian, Lang Chen, Jia Huang, Lihua Yang, Zuocheng Dis Markers Research Article Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance. Hindawi 2018-06-12 /pmc/articles/PMC6020540/ /pubmed/30008974 http://dx.doi.org/10.1155/2018/1064380 Text en Copyright © 2018 Yapeng Lu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lu, Yapeng
Liu, Rui
Zha, Luting
Yuan, Shan
Tian, Lang
Chen, Jia
Huang, Lihua
Yang, Zuocheng
Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_full Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_fullStr Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_full_unstemmed Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_short Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children
title_sort association of thrombomodulin gene c1418t polymorphism with susceptibility to kawasaki disease in chinese children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020540/
https://www.ncbi.nlm.nih.gov/pubmed/30008974
http://dx.doi.org/10.1155/2018/1064380
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