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Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries
BACKGROUND AND OBJECTIVES: Endotracheal intubation is the most important and crucial step during administration of general anesthesia. It is more so in pediatric patients with associated deformities of cleft lip, palate, and alveolus. Propofol, an intravenous (i.v.) induction agent, has profound dep...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020561/ https://www.ncbi.nlm.nih.gov/pubmed/29962612 http://dx.doi.org/10.4103/aer.AER_38_18 |
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author | Karanth, Harish Raveendra, U. S. Shetty, Rithesh B. Shetty, Pramal Thalanjeri, Padmini |
author_facet | Karanth, Harish Raveendra, U. S. Shetty, Rithesh B. Shetty, Pramal Thalanjeri, Padmini |
author_sort | Karanth, Harish |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Endotracheal intubation is the most important and crucial step during administration of general anesthesia. It is more so in pediatric patients with associated deformities of cleft lip, palate, and alveolus. Propofol, an intravenous (i.v.) induction agent, has profound depressant effect on airway reflexes with a quick and smoother induction. Similarly, sevoflurane, an inhalational agent, has relatively pleasant smell, low airway irritability, and more cardiostable properties. Hence, we sought to compare effectiveness of propofol with sevoflurane in achieving good intubation conditions without the use of muscle relaxants. MATERIALS AND METHODS: In this prospective randomized study, eighty children belonging to American Society of Anesthesiologist physical status Class I and II, aged 1–10 years, scheduled for cleft surgery were included. All participants were premedicated. Patients were allotted to Group A and Group B randomly. Group A received propofol and Group B received sevoflurane as induction agents. Tracheal intubation was attempted in all patients at 150 s. Intubation conditions were assessed by using Steyn modification of Helbo–Hansen intubating conditions score. Statistical analysis was done using Student's t-test and Chi-square test with P < 0.05 regarded as significant. RESULTS: Group B patients receiving sevoflurane had significantly more clinically acceptable intubation conditions than patients of Group A receiving i.v. propofol (P = 0.001). CONCLUSION: We conclude that intubation conditions using inhalational 8% sevoflurane are superior to i.v. propofol of 3 mg/kg for tracheal intubation without muscle relaxants in children undergoing cleft surgeries. |
format | Online Article Text |
id | pubmed-6020561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60205612018-06-29 Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries Karanth, Harish Raveendra, U. S. Shetty, Rithesh B. Shetty, Pramal Thalanjeri, Padmini Anesth Essays Res Original Article BACKGROUND AND OBJECTIVES: Endotracheal intubation is the most important and crucial step during administration of general anesthesia. It is more so in pediatric patients with associated deformities of cleft lip, palate, and alveolus. Propofol, an intravenous (i.v.) induction agent, has profound depressant effect on airway reflexes with a quick and smoother induction. Similarly, sevoflurane, an inhalational agent, has relatively pleasant smell, low airway irritability, and more cardiostable properties. Hence, we sought to compare effectiveness of propofol with sevoflurane in achieving good intubation conditions without the use of muscle relaxants. MATERIALS AND METHODS: In this prospective randomized study, eighty children belonging to American Society of Anesthesiologist physical status Class I and II, aged 1–10 years, scheduled for cleft surgery were included. All participants were premedicated. Patients were allotted to Group A and Group B randomly. Group A received propofol and Group B received sevoflurane as induction agents. Tracheal intubation was attempted in all patients at 150 s. Intubation conditions were assessed by using Steyn modification of Helbo–Hansen intubating conditions score. Statistical analysis was done using Student's t-test and Chi-square test with P < 0.05 regarded as significant. RESULTS: Group B patients receiving sevoflurane had significantly more clinically acceptable intubation conditions than patients of Group A receiving i.v. propofol (P = 0.001). CONCLUSION: We conclude that intubation conditions using inhalational 8% sevoflurane are superior to i.v. propofol of 3 mg/kg for tracheal intubation without muscle relaxants in children undergoing cleft surgeries. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6020561/ /pubmed/29962612 http://dx.doi.org/10.4103/aer.AER_38_18 Text en Copyright: © 2018 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Karanth, Harish Raveendra, U. S. Shetty, Rithesh B. Shetty, Pramal Thalanjeri, Padmini Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries |
title | Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries |
title_full | Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries |
title_fullStr | Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries |
title_full_unstemmed | Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries |
title_short | Comparative Evaluation between Sevoflurane and Propofol for Endotracheal Intubation without Muscle Relaxants in Pediatric Cleft Surgeries |
title_sort | comparative evaluation between sevoflurane and propofol for endotracheal intubation without muscle relaxants in pediatric cleft surgeries |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020561/ https://www.ncbi.nlm.nih.gov/pubmed/29962612 http://dx.doi.org/10.4103/aer.AER_38_18 |
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