Cargando…
Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia
OBJECTIVE: Herein, we investigated the balance of thiol/disulfide, with the hypothesis that the balance between disulfides and thiols, which are natural antioxidants, might be disrupted in patients with familial hypercholesterolemia, which eventually leads to endothelial damage. METHODS: In this stu...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020647/ https://www.ncbi.nlm.nih.gov/pubmed/30009049 http://dx.doi.org/10.1155/2018/9042461 |
_version_ | 1783335343341174784 |
---|---|
author | Şimşek, Özgür Çarlıoğlu, Ayşe Alışık, Murat Edem, Efe Biçer, Cemile Koca |
author_facet | Şimşek, Özgür Çarlıoğlu, Ayşe Alışık, Murat Edem, Efe Biçer, Cemile Koca |
author_sort | Şimşek, Özgür |
collection | PubMed |
description | OBJECTIVE: Herein, we investigated the balance of thiol/disulfide, with the hypothesis that the balance between disulfides and thiols, which are natural antioxidants, might be disrupted in patients with familial hypercholesterolemia, which eventually leads to endothelial damage. METHODS: In this study, we evaluated 51 patients diagnosed with familial hypercholesterolemia and 81 healthy subjects. Blood samples were taken from the patients after a minimum of 12 hours of fasting; samples were immediately centrifuged, stored in Eppendorf tubes, and preserved at −80°C. RESULTS: This study found that thiol levels are significantly lower in patients with familial hypercholesterolemia, whereas disulfide levels are higher (independent of age, gender, and body mass index). This means that in such patients, the thiol/disulfide balance changes in favour of disulfide. CONCLUSIONS: In this study, we found that the thiol/disulfide balance in patients with familial hypercholesterolemia is disrupted in favour of disulfide. |
format | Online Article Text |
id | pubmed-6020647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60206472018-07-15 Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia Şimşek, Özgür Çarlıoğlu, Ayşe Alışık, Murat Edem, Efe Biçer, Cemile Koca Cardiol Res Pract Research Article OBJECTIVE: Herein, we investigated the balance of thiol/disulfide, with the hypothesis that the balance between disulfides and thiols, which are natural antioxidants, might be disrupted in patients with familial hypercholesterolemia, which eventually leads to endothelial damage. METHODS: In this study, we evaluated 51 patients diagnosed with familial hypercholesterolemia and 81 healthy subjects. Blood samples were taken from the patients after a minimum of 12 hours of fasting; samples were immediately centrifuged, stored in Eppendorf tubes, and preserved at −80°C. RESULTS: This study found that thiol levels are significantly lower in patients with familial hypercholesterolemia, whereas disulfide levels are higher (independent of age, gender, and body mass index). This means that in such patients, the thiol/disulfide balance changes in favour of disulfide. CONCLUSIONS: In this study, we found that the thiol/disulfide balance in patients with familial hypercholesterolemia is disrupted in favour of disulfide. Hindawi 2018-06-12 /pmc/articles/PMC6020647/ /pubmed/30009049 http://dx.doi.org/10.1155/2018/9042461 Text en Copyright © 2018 Özgür Şimşek et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Şimşek, Özgür Çarlıoğlu, Ayşe Alışık, Murat Edem, Efe Biçer, Cemile Koca Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia |
title | Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia |
title_full | Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia |
title_fullStr | Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia |
title_full_unstemmed | Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia |
title_short | Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia |
title_sort | thiol/disulfide balance in patients with familial hypercholesterolemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020647/ https://www.ncbi.nlm.nih.gov/pubmed/30009049 http://dx.doi.org/10.1155/2018/9042461 |
work_keys_str_mv | AT simsekozgur thioldisulfidebalanceinpatientswithfamilialhypercholesterolemia AT carlıogluayse thioldisulfidebalanceinpatientswithfamilialhypercholesterolemia AT alısıkmurat thioldisulfidebalanceinpatientswithfamilialhypercholesterolemia AT edemefe thioldisulfidebalanceinpatientswithfamilialhypercholesterolemia AT bicercemilekoca thioldisulfidebalanceinpatientswithfamilialhypercholesterolemia |