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Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence

A 56-year-old man was admitted to our hospital for urachal carcinoma with peritoneal dissemination. He received first-line chemotherapy with gemcitabine and cisplatin. After the fifth cycle, a computed tomography (CT) scan revealed abdominal fluid, and his serum tumor marker levels were increased. T...

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Autores principales: Yasui, Masato, Jikuya, Ryosuke, Tatenuma, Tomoyuki, Muraoka, Kentaro, Umemoto, Susumu, Kawai, Masaki, Kouno, Tsutomu, Kishida, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020648/
https://www.ncbi.nlm.nih.gov/pubmed/30009079
http://dx.doi.org/10.1155/2018/9836154
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author Yasui, Masato
Jikuya, Ryosuke
Tatenuma, Tomoyuki
Muraoka, Kentaro
Umemoto, Susumu
Kawai, Masaki
Kouno, Tsutomu
Kishida, Takeshi
author_facet Yasui, Masato
Jikuya, Ryosuke
Tatenuma, Tomoyuki
Muraoka, Kentaro
Umemoto, Susumu
Kawai, Masaki
Kouno, Tsutomu
Kishida, Takeshi
author_sort Yasui, Masato
collection PubMed
description A 56-year-old man was admitted to our hospital for urachal carcinoma with peritoneal dissemination. He received first-line chemotherapy with gemcitabine and cisplatin. After the fifth cycle, a computed tomography (CT) scan revealed abdominal fluid, and his serum tumor marker levels were increased. The patient was started on second-line therapy with FOLFIRI. After 11 cycles, his tumor decreased in size and no new metastatic lesions were detected. The patient underwent complete tumor resection with partial cystectomy and pelvic lymph node dissection. The tumor was removed, along with adhering surrounding organs, including the omentum, peritoneum, abdominal rectus muscle, and vermiform appendix. Although pathological examination confirmed peritoneal dissemination, his tumor markers normalized soon after surgery. The patient has survived 62 months after surgery without any adjuvant therapy and with no evidence of recurrence. To our knowledge, this is the longest duration of survival without recurrence of a patient with urachal carcinoma with peritoneal dissemination who received multimodal therapy.
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spelling pubmed-60206482018-07-15 Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence Yasui, Masato Jikuya, Ryosuke Tatenuma, Tomoyuki Muraoka, Kentaro Umemoto, Susumu Kawai, Masaki Kouno, Tsutomu Kishida, Takeshi Case Rep Urol Case Report A 56-year-old man was admitted to our hospital for urachal carcinoma with peritoneal dissemination. He received first-line chemotherapy with gemcitabine and cisplatin. After the fifth cycle, a computed tomography (CT) scan revealed abdominal fluid, and his serum tumor marker levels were increased. The patient was started on second-line therapy with FOLFIRI. After 11 cycles, his tumor decreased in size and no new metastatic lesions were detected. The patient underwent complete tumor resection with partial cystectomy and pelvic lymph node dissection. The tumor was removed, along with adhering surrounding organs, including the omentum, peritoneum, abdominal rectus muscle, and vermiform appendix. Although pathological examination confirmed peritoneal dissemination, his tumor markers normalized soon after surgery. The patient has survived 62 months after surgery without any adjuvant therapy and with no evidence of recurrence. To our knowledge, this is the longest duration of survival without recurrence of a patient with urachal carcinoma with peritoneal dissemination who received multimodal therapy. Hindawi 2018-06-13 /pmc/articles/PMC6020648/ /pubmed/30009079 http://dx.doi.org/10.1155/2018/9836154 Text en Copyright © 2018 Masato Yasui et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yasui, Masato
Jikuya, Ryosuke
Tatenuma, Tomoyuki
Muraoka, Kentaro
Umemoto, Susumu
Kawai, Masaki
Kouno, Tsutomu
Kishida, Takeshi
Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence
title Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence
title_full Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence
title_fullStr Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence
title_full_unstemmed Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence
title_short Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence
title_sort urachal carcinoma with peritoneal dissemination treated with chemotherapy and surgical resection leading to prolonged survival with no recurrence
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020648/
https://www.ncbi.nlm.nih.gov/pubmed/30009079
http://dx.doi.org/10.1155/2018/9836154
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