TP53 Mutation as Potential Negative Predictor for Response of Anti-CTLA-4 Therapy in Metastatic Melanoma

TP53 has been proved to be associated with cytotoxic T-cell induced apoptosis, however, the association between TP53 and the benefit of immunotherapy in melanoma has not been studied. In the present study, we examined the relationship between TP53 mutation and response to CTLA-4 blockade in metastat...

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Detalles Bibliográficos
Autores principales: Xiao, Wenjing, Du, Nan, Huang, Taoyuan, Guo, Jinan, Mo, Xingkui, Yuan, Tao, Chen, Yong, Ye, Ting, Xu, Chunwei, Wang, Wenxian, Wang, Guoqiang, Cai, Shangli, Chen, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020711/
https://www.ncbi.nlm.nih.gov/pubmed/29793878
http://dx.doi.org/10.1016/j.ebiom.2018.05.019

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