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Role of extracellular matrix in breast cancer development: a brief update
Evidence is increasing on the crucial role of the extracellular matrix (ECM) in breast cancer progression, invasion and metastasis with almost all mortality cases owing to metastasis. The epithelial-mesenchymal transition is the first signal of metastasis involving different transcription factors su...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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F1000 Research Limited
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020719/ https://www.ncbi.nlm.nih.gov/pubmed/29983921 http://dx.doi.org/10.12688/f1000research.14133.2 |
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author | Jena, Manoj Kumar Janjanam, Jagadeesh |
author_facet | Jena, Manoj Kumar Janjanam, Jagadeesh |
author_sort | Jena, Manoj Kumar |
collection | PubMed |
description | Evidence is increasing on the crucial role of the extracellular matrix (ECM) in breast cancer progression, invasion and metastasis with almost all mortality cases owing to metastasis. The epithelial-mesenchymal transition is the first signal of metastasis involving different transcription factors such as Snail, TWIST, and ZEB1. ECM remodeling is a major event promoting cancer invasion and metastasis; where matrix metalloproteinases (MMPs) such as MMP-2, -9, -11, and -14 play vital roles degrading the matrix proteins for cancer spread. The β-D mannuronic acid (MMP inhibitor) has anti-metastatic properties through inhibition of MMP-2, and -9 and could be a potential therapeutic agent. Besides the MMPs, the enzymes such as LOXL2, LOXL4, procollagen lysyl hydroxylase-2, and heparanase also regulate breast cancer progression. The important ECM proteins like integrins (b1-, b5-, and b6- integrins), ECM1 protein, and Hic-5 protein are also actively involved in breast cancer development. The stromal cells such as tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and adipocytes also contribute in tumor development through different processes. The TAMs become proangiogenic through secretion of VEGF-A and building vessel network for nourishment and invasion of the tumor mass. The latest developments of ECM involvement in breast cancer progression has been discussed in this review and this study will help researchers in designing future work on breast cancer pathogenesis and developing therapy targeted to the ECM components. |
format | Online Article Text |
id | pubmed-6020719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-60207192018-07-06 Role of extracellular matrix in breast cancer development: a brief update Jena, Manoj Kumar Janjanam, Jagadeesh F1000Res Review Evidence is increasing on the crucial role of the extracellular matrix (ECM) in breast cancer progression, invasion and metastasis with almost all mortality cases owing to metastasis. The epithelial-mesenchymal transition is the first signal of metastasis involving different transcription factors such as Snail, TWIST, and ZEB1. ECM remodeling is a major event promoting cancer invasion and metastasis; where matrix metalloproteinases (MMPs) such as MMP-2, -9, -11, and -14 play vital roles degrading the matrix proteins for cancer spread. The β-D mannuronic acid (MMP inhibitor) has anti-metastatic properties through inhibition of MMP-2, and -9 and could be a potential therapeutic agent. Besides the MMPs, the enzymes such as LOXL2, LOXL4, procollagen lysyl hydroxylase-2, and heparanase also regulate breast cancer progression. The important ECM proteins like integrins (b1-, b5-, and b6- integrins), ECM1 protein, and Hic-5 protein are also actively involved in breast cancer development. The stromal cells such as tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and adipocytes also contribute in tumor development through different processes. The TAMs become proangiogenic through secretion of VEGF-A and building vessel network for nourishment and invasion of the tumor mass. The latest developments of ECM involvement in breast cancer progression has been discussed in this review and this study will help researchers in designing future work on breast cancer pathogenesis and developing therapy targeted to the ECM components. F1000 Research Limited 2018-06-12 /pmc/articles/PMC6020719/ /pubmed/29983921 http://dx.doi.org/10.12688/f1000research.14133.2 Text en Copyright: © 2018 Jena MK and Janjanam J http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Jena, Manoj Kumar Janjanam, Jagadeesh Role of extracellular matrix in breast cancer development: a brief update |
title | Role of extracellular matrix in breast cancer development: a brief update |
title_full | Role of extracellular matrix in breast cancer development: a brief update |
title_fullStr | Role of extracellular matrix in breast cancer development: a brief update |
title_full_unstemmed | Role of extracellular matrix in breast cancer development: a brief update |
title_short | Role of extracellular matrix in breast cancer development: a brief update |
title_sort | role of extracellular matrix in breast cancer development: a brief update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020719/ https://www.ncbi.nlm.nih.gov/pubmed/29983921 http://dx.doi.org/10.12688/f1000research.14133.2 |
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