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Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity

Background: Class IA phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) is an integral mediator of insulin signaling. The p110 catalytic and p85 regulatory subunits of PI3K are the products of separate genes, and while they come together to make the active heterodimer, they have opposing roles in...

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Detalles Bibliográficos
Autores principales:	Chaudhari, Aditi, Ejeskär, Katarina, Wettergren, Yvonne, Kahn, C. Ronald, Rotter Sopasakis, Victoria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020741/ https://www.ncbi.nlm.nih.gov/pubmed/29983910 http://dx.doi.org/10.12688/f1000research.12418.2

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