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4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

Acetaminophen (APAP) overdose is the principal cause of drug-induced acute liver failure. 4-hydroxyphenylacetic acid (4-HPA), a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. This study seeks to investigate the ability of 4-HPA to protect against APAP-in...

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Detalles Bibliográficos
Autores principales:	Zhao, Hongqiong, Jiang, Zhihui, Chang, Xuemei, Xue, Huiting, Yahefu, Wumaierjiang, Zhang, Xiaoying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020787/ https://www.ncbi.nlm.nih.gov/pubmed/29973881 http://dx.doi.org/10.3389/fphar.2018.00653

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