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LncRNAs in genetic basis of glaucoma

Glaucoma is an umbrella term used to designate a heterogeneous group of ocular disorders characterised by progressive excavation of the optic disc, optic atrophy and gradual loss of the visual field caused by the slow death of retinal ganglion cells and their axons. Glaucoma can potentially lead to...

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Autores principales: Cissé, Yacouba, Bai, Lang, Meng, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020790/
https://www.ncbi.nlm.nih.gov/pubmed/29963644
http://dx.doi.org/10.1136/bmjophth-2017-000131
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author Cissé, Yacouba
Bai, Lang
Meng, Ting
author_facet Cissé, Yacouba
Bai, Lang
Meng, Ting
author_sort Cissé, Yacouba
collection PubMed
description Glaucoma is an umbrella term used to designate a heterogeneous group of ocular disorders characterised by progressive excavation of the optic disc, optic atrophy and gradual loss of the visual field caused by the slow death of retinal ganglion cells and their axons. Glaucoma can potentially lead to blindness if left untreated. It usually starts from the periphery and progresses gradually toward the centre of the visual field. Vision loss caused by glaucoma is irreversible and causes a heavy burden on affected families and society, therefore the importance of early diagnosis and prevention should be emphasised. Genetic factors appear to play a role in glaucoma pathogenesis; it has been shown that individuals with a positive family history are at a greater risk because they are more likely predisposed be affected. Notable advances have been recorded in the past decade concerning the genetic and environmental factors likely to contribute or cause glaucoma with the discovery of multiple glaucoma-associated genes and genetic loci. Thorough investigations by a handful of studies on the function of long non-coding RNAs discovered that, although lacking protein-coding potential, lncRNAs can still participate in the regulation of gene expression at various levels, thus their possible implication in different disease aetiologies. In this review, we focus on the lncRNAs characteristics and its regulation, and summarise these results from separate, independent, glaucoma-related studies in addition to discussing possible pathways by which lncRNAs might contribute to glaucoma.
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spelling pubmed-60207902018-06-29 LncRNAs in genetic basis of glaucoma Cissé, Yacouba Bai, Lang Meng, Ting BMJ Open Ophthalmol Review Glaucoma is an umbrella term used to designate a heterogeneous group of ocular disorders characterised by progressive excavation of the optic disc, optic atrophy and gradual loss of the visual field caused by the slow death of retinal ganglion cells and their axons. Glaucoma can potentially lead to blindness if left untreated. It usually starts from the periphery and progresses gradually toward the centre of the visual field. Vision loss caused by glaucoma is irreversible and causes a heavy burden on affected families and society, therefore the importance of early diagnosis and prevention should be emphasised. Genetic factors appear to play a role in glaucoma pathogenesis; it has been shown that individuals with a positive family history are at a greater risk because they are more likely predisposed be affected. Notable advances have been recorded in the past decade concerning the genetic and environmental factors likely to contribute or cause glaucoma with the discovery of multiple glaucoma-associated genes and genetic loci. Thorough investigations by a handful of studies on the function of long non-coding RNAs discovered that, although lacking protein-coding potential, lncRNAs can still participate in the regulation of gene expression at various levels, thus their possible implication in different disease aetiologies. In this review, we focus on the lncRNAs characteristics and its regulation, and summarise these results from separate, independent, glaucoma-related studies in addition to discussing possible pathways by which lncRNAs might contribute to glaucoma. BMJ Publishing Group 2018-03-29 /pmc/articles/PMC6020790/ /pubmed/29963644 http://dx.doi.org/10.1136/bmjophth-2017-000131 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Cissé, Yacouba
Bai, Lang
Meng, Ting
LncRNAs in genetic basis of glaucoma
title LncRNAs in genetic basis of glaucoma
title_full LncRNAs in genetic basis of glaucoma
title_fullStr LncRNAs in genetic basis of glaucoma
title_full_unstemmed LncRNAs in genetic basis of glaucoma
title_short LncRNAs in genetic basis of glaucoma
title_sort lncrnas in genetic basis of glaucoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020790/
https://www.ncbi.nlm.nih.gov/pubmed/29963644
http://dx.doi.org/10.1136/bmjophth-2017-000131
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