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Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper

Amyloidosis is a clinical disorder implicated with the formation of toxic amyloid aggregates. Despite their pathological significance, it is challenging to define the structural characteristics of amyloid oligomers owing to their metastable nature. Herein, we report structural and mechanistic invest...

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Detalles Bibliográficos
Autores principales:	Lee, Shin Jung C., Choi, Tae Su, Lee, Jong Wha, Lee, Hyuck Jin, Mun, Dong-Gi, Akashi, Satoko, Lee, Sang-Won, Lim, Mi Hee, Kim, Hugh I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020819/ https://www.ncbi.nlm.nih.gov/pubmed/30155193 http://dx.doi.org/10.1039/c6sc00153j

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