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Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates

Pathogenic Escherichia coli, one of the primary causes of urinary tract infections, has shown significant resistance to the most popular antibiotic, trimethoprim (TMP), which inhibits dihydrofolate reductase (DHFR). The resistance is modulated by single point mutations of DHFR. The impact of two cli...

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Detalles Bibliográficos
Autores principales:	Cammarata, Michael, Thyer, Ross, Lombardo, Michael, Anderson, Amy, Wright, Dennis, Ellington, Andrew, Brodbelt, Jennifer S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020862/ https://www.ncbi.nlm.nih.gov/pubmed/29967675 http://dx.doi.org/10.1039/c6sc05235e

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