Cargando…

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

PURPOSE: Liver fibrosis is commonly seen and a necessary stage in chronic liver disease. The aim of this study was to explore the effect of salidroside on liver fibrosis in mice and its potential mechanisms. MATERIALS AND METHODS: Two mouse liver fibrosis models were established by intraperitoneal i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Jiao, Chen, Kan, Xia, Yujing, Wu, Liwei, Li, Jingjing, Li, Sainan, Wang, Wenwen, Lu, Xiya, Liu, Tong, Guo, Chuanyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021006/ https://www.ncbi.nlm.nih.gov/pubmed/29970958 http://dx.doi.org/10.2147/DDDT.S162950

Ejemplares similares

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways
por: Wu, Liwei, et al.
Publicado: (2017)

Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury
por: Feng, Jiao, et al.
Publicado: (2018)

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway
por: Wu, Liwei, et al.
Publicado: (2017)

Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity
por: Mo, Wenhui, et al.
Publicado: (2018)

Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia–reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice
por: Feng, Jiao, et al.
Publicado: (2017)

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy
por: Li, Jingjing, et al.
Publicado: (2016)

Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways
por: Ji, Jie, et al.
Publicado: (2021)

Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway
por: Xia, Yujing, et al.
Publicado: (2020)

Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways
por: Li, Rui, et al.
Publicado: (2019)

PPARγ/NF‐κB and TGF‐β1/Smad pathway are involved in the anti‐fibrotic effects of levo‐tetrahydropalmatine on liver fibrosis
por: Yu, Qiang, et al.
Publicado: (2021)

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3
por: Li, Sainan, et al.
Publicado: (2016)

Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats
por: Gao, Hui, et al.
Publicado: (2020)

3-Methyladenine ameliorates liver fibrosis through autophagy regulated by the NF-κB signaling pathways on hepatic stellate cell
por: Wang, Bingying, et al.
Publicado: (2017)

Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways
por: Lin, Liteng, et al.
Publicado: (2018)

Salidroside Ameliorates Ultraviolet-Induced Keratinocyte Injury by Inducing SIRT1-Dependent Autophagy
por: Ke, Jin, et al.
Publicado: (2022)

Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways
por: Yao, Lan, et al.
Publicado: (2019)

Probiotics counteract the expression of hepatic profibrotic genes via the attenuation of TGF-β/SMAD signaling and autophagy in hepatic stellate cells
por: Kanmani, Paulraj, et al.
Publicado: (2022)

Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy
por: Zheng, Zhi-chao, et al.
Publicado: (2020)

Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model
por: Yang, Kang, et al.
Publicado: (2020)

Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2
por: Tee, Jie Kai, et al.
Publicado: (2018)

Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating Akt/NF-κB and caspase-3/GSDME pathways
por: Wang, Xiaohong, et al.
Publicado: (2023)

Effect of Exogenous Fetuin-A on TGF-β/Smad Signaling in Hepatic Stellate Cells
por: Zhou, Yulai, et al.
Publicado: (2016)

Mindin deficiency alleviates renal fibrosis through inhibiting NF‐κB and TGF‐β/Smad pathways
por: Yang, Kang, et al.
Publicado: (2020)

Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway
por: Li, Jialin, et al.
Publicado: (2022)

TGF‐β/Smad and JAK/STAT pathways are involved in the anti‐fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis
por: Xu, Shizan, et al.
Publicado: (2020)

Smad7-overexpressing rat BMSCs inhibit the fibrosis of hepatic stellate cells by regulating the TGF-β1/Smad signaling pathway
por: Wu, Shi-Pin, et al.
Publicado: (2017)

The long noncoding RNA TUG1 acts as a competing endogenous RNA to regulate the Hedgehog pathway by targeting miR-132 in hepatocellular carcinoma
por: Li, Jingjing, et al.
Publicado: (2017)

Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death
por: Li, Sainan, et al.
Publicado: (2017)

The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity
por: Xu, Shizan, et al.
Publicado: (2017)

Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro
por: Li, Jingjing, et al.
Publicado: (2015)

Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer
por: Peng, Xiongqun, et al.
Publicado: (2023)

Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis
por: Feng, Jiao, et al.
Publicado: (2019)

Salidroside Inhibits Myogenesis by Modulating p-Smad3-Induced Myf5 Transcription
por: Zhang, Peng, et al.
Publicado: (2018)

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma
por: Wang, Hui, et al.
Publicado: (2015)

Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1
por: Lan, Kuo-Cheng, et al.
Publicado: (2017)

Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway
por: Chai, Yuhui, et al.
Publicado: (2022)

Petchiether A attenuates obstructive nephropathy by suppressing TGF‐β/Smad3 and NF‐κB signalling
por: You, Yong‐Ke, et al.
Publicado: (2019)

Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells
por: Kataoka, Seita, et al.
Publicado: (2021)

Cinobufacini Inhibits the Development of Pancreatic Cancer Cells through the TGFβ/Smads Pathway of Pancreatic Stellate Cells
por: Li, Quan-Wang, et al.
Publicado: (2022)

Trimetazidine inhibits liver fibrosis and hepatic stellate cell proliferation and blocks transforming growth factor-β (TGFβ)/Smad signaling in vitro and in vivo
por: Ding, Wenwen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7fm2j83nk37j6s89irobko4saa