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Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis

BACKGROUND: The purpose of this research was to determine whether neck dissection is necessary for the adenoid cystic carcinoma (ACC) of head and neck. MATERIALS AND METHODS: This article screened the abstract and full-text papers that investigated salivary gland primary ACC of head and neck. Two in...

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Autores principales: Ning, Chunliu, Zhao, Tengfei, Wang, Zechen, Li, Delong, Kou, Yurong, Huang, Shaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021008/
https://www.ncbi.nlm.nih.gov/pubmed/29970966
http://dx.doi.org/10.2147/CMAR.S164677
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author Ning, Chunliu
Zhao, Tengfei
Wang, Zechen
Li, Delong
Kou, Yurong
Huang, Shaohui
author_facet Ning, Chunliu
Zhao, Tengfei
Wang, Zechen
Li, Delong
Kou, Yurong
Huang, Shaohui
author_sort Ning, Chunliu
collection PubMed
description BACKGROUND: The purpose of this research was to determine whether neck dissection is necessary for the adenoid cystic carcinoma (ACC) of head and neck. MATERIALS AND METHODS: This article screened the abstract and full-text papers that investigated salivary gland primary ACC of head and neck. Two independent reviewers searched for articles published before October 2017 in three databases (Web of Science, PubMed, and Ovid), having no limits in date and language. Statistical data were analyzed statistically by Review Manager 5.3. RESULTS: In total, 18 studies involving 2993 patients were included in the analysis. Of the 2993 patients, 473 patients had cervical lymph node metastasis, with a merge frequency of 16% (95% CI: 13–19). Among included articles, only 4 involved cervical lymph node occult metastases, with a merge frequency of 14% (95% CI: 9–20). There were 5 articles containing minor salivary glands (MiSGs) involving 370 patients of which 92 patients had cervical lymph node metastases and the merge frequency was 25% (95% CI: 11–38). Moreover, there were 4 studies on major salivary glands involving 904 patients of which 158 patients had cervical lymph node metastases and the merge frequency was 17% (95% CI: 15–20). CONCLUSION: Elective neck dissection is unnecessary for all patients with salivary gland ACC of head and neck. Moreover, compared with major salivary glands, MiSGs have a higher cervical lymph node metastases rate in ACC. The overall cervical lymph node metastases rate of MiSGs is 25%, which is enough to attract our attention. Therefore, we suggest that neck dissection might be applied to ACC of MiSGs.
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spelling pubmed-60210082018-07-03 Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis Ning, Chunliu Zhao, Tengfei Wang, Zechen Li, Delong Kou, Yurong Huang, Shaohui Cancer Manag Res Original Research BACKGROUND: The purpose of this research was to determine whether neck dissection is necessary for the adenoid cystic carcinoma (ACC) of head and neck. MATERIALS AND METHODS: This article screened the abstract and full-text papers that investigated salivary gland primary ACC of head and neck. Two independent reviewers searched for articles published before October 2017 in three databases (Web of Science, PubMed, and Ovid), having no limits in date and language. Statistical data were analyzed statistically by Review Manager 5.3. RESULTS: In total, 18 studies involving 2993 patients were included in the analysis. Of the 2993 patients, 473 patients had cervical lymph node metastasis, with a merge frequency of 16% (95% CI: 13–19). Among included articles, only 4 involved cervical lymph node occult metastases, with a merge frequency of 14% (95% CI: 9–20). There were 5 articles containing minor salivary glands (MiSGs) involving 370 patients of which 92 patients had cervical lymph node metastases and the merge frequency was 25% (95% CI: 11–38). Moreover, there were 4 studies on major salivary glands involving 904 patients of which 158 patients had cervical lymph node metastases and the merge frequency was 17% (95% CI: 15–20). CONCLUSION: Elective neck dissection is unnecessary for all patients with salivary gland ACC of head and neck. Moreover, compared with major salivary glands, MiSGs have a higher cervical lymph node metastases rate in ACC. The overall cervical lymph node metastases rate of MiSGs is 25%, which is enough to attract our attention. Therefore, we suggest that neck dissection might be applied to ACC of MiSGs. Dove Medical Press 2018-06-22 /pmc/articles/PMC6021008/ /pubmed/29970966 http://dx.doi.org/10.2147/CMAR.S164677 Text en © 2018 Ning et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ning, Chunliu
Zhao, Tengfei
Wang, Zechen
Li, Delong
Kou, Yurong
Huang, Shaohui
Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis
title Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis
title_full Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis
title_fullStr Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis
title_full_unstemmed Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis
title_short Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis
title_sort cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021008/
https://www.ncbi.nlm.nih.gov/pubmed/29970966
http://dx.doi.org/10.2147/CMAR.S164677
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