Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing

Genetic mutations in TP53 contribute to multiple human cancers. Here we report the generation of a H1-p53(R248W/R248W) human embryonic stem cell line harboring a homozygous TP53 R248W mutation created by TALEN-mediated precise gene editing. The H1-p53(R248W/R248W) cell line maintains a normal karyot...

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Detalles Bibliográficos
Autores principales: Xu, An, Zhou, Ruoji, Tu, Jian, Huo, Zijun, Zhu, Dandan, Wang, Donghui, Gingold, Julian A., Mata, Helen, Rao, Pulivarthi H., Liu, Mo, Mohamed, Alaa M.T., Kong, Celine Shuet Lin, Jewell, Brittany E., Xia, Weiya, Zhao, Ruiying, Hung, Mien-Chie, Lee, Dung-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021017/
https://www.ncbi.nlm.nih.gov/pubmed/29730572
http://dx.doi.org/10.1016/j.scr.2018.04.013

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