Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles

Dysfunctional endothelial cells contribute to the pathophysiology of many diseases, including vascular disease, stroke, hypertension, atherosclerosis, organ failure, diabetes, retinopathy, and cancer. Toward the goal of creating a new RNA-based therapy to correct aberrant endothelial cell gene expre...

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Detalles Bibliográficos
Autores principales: Khan, Omar F., Kowalski, Piotr S., Doloff, Joshua C., Tsosie, Jonathan K., Bakthavatchalu, Vasudevan, Winn, Caroline Bodi, Haupt, Jennifer, Jamiel, Morgan, Langer, Robert, Anderson, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021147/
https://www.ncbi.nlm.nih.gov/pubmed/29963629
http://dx.doi.org/10.1126/sciadv.aar8409

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