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Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan

Nodes of Ranvier are unique regions where voltage-gated sodium channels are highly enriched to drive saltatory conduction. Genetic ablations in adult mice with loss of specific nodal proteins causes slow but progressive nodal deterioration associated with decreased nerve conduction and axonopathy. W...

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Detalles Bibliográficos
Autores principales:	Taylor, Anna M., Shi, Qian, Bhat, Manzoor A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2018
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021167/ https://www.ncbi.nlm.nih.gov/pubmed/29963618 http://dx.doi.org/10.1523/ENEURO.0138-18.2018

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