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A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II

The end of the RNA polymerase II (Pol II) transcription cycle is strictly regulated to prevent interference between neighbouring genes and safeguard transcriptome integrity(1). Pol II accumulation downstream of the cleavage and polyadenylation signal (CPS) can facilitate recruitment of factors invol...

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Detalles Bibliográficos
Autores principales: Parua, Pabitra K., Booth, Gregory T., Sansó, Miriam, Benjamin, Bradley, Tanny, Jason C., Lis, John T., Fisher, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021199/
https://www.ncbi.nlm.nih.gov/pubmed/29899453
http://dx.doi.org/10.1038/s41586-018-0214-z