Cargando…

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse

INTRODUCTION: Translational inhibition of amyloid precursor protein (APP) by Posiphen has been shown to reduce APP and its fragments in cell culture, animal models, and mildly cognitively impaired patients, making it a promising drug candidate for the treatment of Alzheimer's disease. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teich, Andrew F., Sharma, Ekta, Barnwell, Eliza, Zhang, Hong, Staniszewski, Agnieszka, Utsuki, Tadanobu, Padmaraju, Vasudevaraju, Mazell, Cheryl, Tzekou, Apostolia, Sambamurti, Kumar, Arancio, Ottavio, Maccecchini, Maria L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021259/ https://www.ncbi.nlm.nih.gov/pubmed/29955650 http://dx.doi.org/10.1016/j.trci.2017.12.001

Ejemplares similares

Targeting increased levels of APP in Down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model
por: Chen, Xu‐Qiao, et al.
Publicado: (2020)

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression
por: Chen, Xu-Qiao, et al.
Publicado: (2021)

Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein
por: Barnwell, Eliza, et al.
Publicado: (2014)

Cell Biology Apps for Apple Devices
por: Stark, Louisa A.
Publicado: (2012)

Apps: A way to accelerate recovery?
por: Westgarth, David
Publicado: (2021)

Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice
por: Gnanaprakash, Madhumathi, et al.
Publicado: (2021)

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans
por: Maccecchini, Maria L, et al.
Publicado: (2012)

Hematologic safety of chronic brain-penetrating erythropoietin dosing in APP/PS1 mice
por: Sun, Jiahong, et al.
Publicado: (2019)

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent
por: Puzzo, Daniela, et al.
Publicado: (2017)

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
por: Tamayev, Robert, et al.
Publicado: (2012)

Memory matters in dementia: Efficacy of a mobile reminiscing therapy app
por: Yu, Fang, et al.
Publicado: (2019)

New insight into Alzheimer's disease: Light reverses Aβ-obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice
por: Yue, Xiangpei, et al.
Publicado: (2019)

A Reliable Way to Detect Endogenous Murine β-Amyloid
por: Teich, Andrew F., et al.
Publicado: (2013)

Pharmocologic treatment with histone deacetylase 6 inhibitor (ACY-738) recovers Alzheimer's disease phenotype in amyloid precursor protein/presenilin 1 (APP/PS1) mice
por: Majid, Tabassum, et al.
Publicado: (2015)

APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
por: Jordà‐Siquier, Tomàs, et al.
Publicado: (2022)

Post-treatment with Posiphen Reduces Endoplasmic Reticulum Stress and Neurodegeneration in Stroke Brain
por: Yu, Seong-Jin, et al.
Publicado: (2020)

A pilot exploration with Posiphen to normalize amyloid precursor protein in Down syndrome
por: Chen, Xu-Qiao
Publicado: (2021)

Dynamin 1 Is Required for Memory Formation
por: Fà, Mauro, et al.
Publicado: (2014)

Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
por: Kirsebom, Bjørn-Eivind, et al.
Publicado: (2018)

Treatment of Spinal Cord Injury with Intravenous Immunoglobulin G: Preliminary Evidence and Future Perspectives
por: Tzekou, Apostolia, et al.
Publicado: (2014)

Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke
por: Turcato, Flavia, et al.
Publicado: (2018)

Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia
por: Willis, Brian A., et al.
Publicado: (2018)

WhatsApp: What an App!
por: Thota, Raghu S., et al.
Publicado: (2015)

Android apps with App Inventor: the fast and easy way to build Android apps
por: Kloss, Jörg H
Publicado: (2012)

The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5′Untranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression
por: Mikkilineni, Sohan, et al.
Publicado: (2012)

In Silico and Ex Vivo Analyses of the Inhibitory Action of the Alzheimer Drug Posiphen and Primary Metabolites with Human Acetyl- and Butyrylcholinesterase Enzymes
por: Batool, Sidra, et al.
Publicado: (2022)

Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice
por: Chen, Lizhi, et al.
Publicado: (2019)

App accomplished : strategies for app development success
por: Brown, Carl
Publicado: (2015)

Essential App Engine: building high performance Java apps with Google App Engine
por: De Jonge, Adriaan
Publicado: (2011)

Use of a Meter With Color-Range Indicators and a Mobile Diabetes Management App Improved Glycemic Control and Patient Satisfaction in an Underserved Hispanic Population: “Tu Salud”—A Randomized Controlled Partial Cross-Over Clinical Study
por: Katz, Laurence B., et al.
Publicado: (2022)

PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease
por: Teich, Andrew F., et al.
Publicado: (2016)

Differential Rickettsial Transcription in Bloodfeeding and Non-Bloodfeeding Arthropod Hosts
por: Verhoeve, Victoria I., et al.
Publicado: (2016)

Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Carney, Rosalind S.E.
Publicado: (2019)

Description of Cardiological Apps From the German App Store: Semiautomated Retrospective App Store Analysis
por: Albrecht, Urs-Vito, et al.
Publicado: (2018)

Effects of experimental cervical spinal cord injury on peripheral adaptive immunity
por: Ulndreaj, Antigona, et al.
Publicado: (2020)

App features that fulfill parents’ needs in apps for children
por: Broekman, Francette L., et al.
Publicado: (2018)

Where Do We Go From Here?: The Impact of COVID-19 on Practice Readiness and Considerations for Nurse Leaders
por: Grubaugh, Martha, et al.
Publicado: (2022)

Immune senescence in aged APP/PS1 mice
por: Abdelmoaty, Mai M., et al.
Publicado: (2023)

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice
por: Shen, Yang, et al.
Publicado: (2020)

App Inventor
por: Wolber, David, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_bb46j4cqc1rob6nd3bnq2kd63l