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Measuring cognition and function in the preclinical stage of Alzheimer's disease
The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for pre...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021264/ https://www.ncbi.nlm.nih.gov/pubmed/29955653 http://dx.doi.org/10.1016/j.trci.2018.01.003 |
| _version_ | 1783335435905269760 |
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| author | Weintraub, Sandra Carrillo, Maria C. Farias, Sarah Tomaszewski Goldberg, Terry E. Hendrix, James A. Jaeger, Judith Knopman, David S. Langbaum, Jessica B. Park, Denise C. Ropacki, Michael T. Sikkes, Sietske A.M. Welsh-Bohmer, Kathleen A. Bain, Lisa J. Brashear, Robert Budur, Kumar Graf, Ana Martenyi, Ferenc Storck, Marta Segardahl Randolph, Christopher |
| author_facet | Weintraub, Sandra Carrillo, Maria C. Farias, Sarah Tomaszewski Goldberg, Terry E. Hendrix, James A. Jaeger, Judith Knopman, David S. Langbaum, Jessica B. Park, Denise C. Ropacki, Michael T. Sikkes, Sietske A.M. Welsh-Bohmer, Kathleen A. Bain, Lisa J. Brashear, Robert Budur, Kumar Graf, Ana Martenyi, Ferenc Storck, Marta Segardahl Randolph, Christopher |
| author_sort | Weintraub, Sandra |
| collection | PubMed |
| description | The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti-Amyloid Treatment in Asymptomatic Alzheimer's to compare current approaches and tools that are being developed. |
| format | Online Article Text |
| id | pubmed-6021264 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60212642018-06-28 Measuring cognition and function in the preclinical stage of Alzheimer's disease Weintraub, Sandra Carrillo, Maria C. Farias, Sarah Tomaszewski Goldberg, Terry E. Hendrix, James A. Jaeger, Judith Knopman, David S. Langbaum, Jessica B. Park, Denise C. Ropacki, Michael T. Sikkes, Sietske A.M. Welsh-Bohmer, Kathleen A. Bain, Lisa J. Brashear, Robert Budur, Kumar Graf, Ana Martenyi, Ferenc Storck, Marta Segardahl Randolph, Christopher Alzheimers Dement (N Y) Perspective The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti-Amyloid Treatment in Asymptomatic Alzheimer's to compare current approaches and tools that are being developed. Elsevier 2018-02-13 /pmc/articles/PMC6021264/ /pubmed/29955653 http://dx.doi.org/10.1016/j.trci.2018.01.003 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Perspective Weintraub, Sandra Carrillo, Maria C. Farias, Sarah Tomaszewski Goldberg, Terry E. Hendrix, James A. Jaeger, Judith Knopman, David S. Langbaum, Jessica B. Park, Denise C. Ropacki, Michael T. Sikkes, Sietske A.M. Welsh-Bohmer, Kathleen A. Bain, Lisa J. Brashear, Robert Budur, Kumar Graf, Ana Martenyi, Ferenc Storck, Marta Segardahl Randolph, Christopher Measuring cognition and function in the preclinical stage of Alzheimer's disease |
| title | Measuring cognition and function in the preclinical stage of Alzheimer's disease |
| title_full | Measuring cognition and function in the preclinical stage of Alzheimer's disease |
| title_fullStr | Measuring cognition and function in the preclinical stage of Alzheimer's disease |
| title_full_unstemmed | Measuring cognition and function in the preclinical stage of Alzheimer's disease |
| title_short | Measuring cognition and function in the preclinical stage of Alzheimer's disease |
| title_sort | measuring cognition and function in the preclinical stage of alzheimer's disease |
| topic | Perspective |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021264/ https://www.ncbi.nlm.nih.gov/pubmed/29955653 http://dx.doi.org/10.1016/j.trci.2018.01.003 |
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