Cargando…

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth

Despite recent progress in diagnosis and treatment, survival for children with high-risk metastatic neuroblastoma is still poor. Prostaglandin E(2) (PGE(2))-driven inflammation promotes tumor growth, immune suppression, angiogenesis and resistance to established cancer therapies. In neuroblastoma, c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kock, Anna, Larsson, Karin, Bergqvist, Filip, Eissler, Nina, Elfman, Lotta H.M., Raouf, Joan, Korotkova, Marina, Johnsen, John Inge, Jakobsson, Per-Johan, Kogner, Per
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021299/ https://www.ncbi.nlm.nih.gov/pubmed/29804818 http://dx.doi.org/10.1016/j.ebiom.2018.05.008

Ejemplares similares

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases
por: Korotkova, Marina, et al.
Publicado: (2011)

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E(2) Synthase 1 and Ser127 Is Not
por: Raouf, Joan, et al.
Publicado: (2016)

Immune suppression by myeloid-derived suppressor cells, MDSCs, in MYCN-driven neuroblastoma provides a potential target for cancer immunotherapy
por: Eissler, Nina, et al.
Publicado: (2014)

Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies
por: Korotkova, M, et al.
Publicado: (2005)

Autocrine Prostaglandin E(2) Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma
por: Rasmuson, Agnes, et al.
Publicado: (2012)

Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen
por: Revathikumar, Priya, et al.
Publicado: (2018)

Correction: Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen
por: Revathikumar, Priya, et al.
Publicado: (2018)

Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium
por: Korotkova, M, et al.
Publicado: (2004)

Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma
por: Hald, Øyvind H., et al.
Publicado: (2018)

Tumor Development, Growth Characteristics and Spectrum of Genetic Aberrations in the TH-MYCN Mouse Model of Neuroblastoma
por: Rasmuson, Agnes, et al.
Publicado: (2012)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
por: Sampey, Annaleise V, et al.
Publicado: (2005)

Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo
por: Tümmler, Conny, et al.
Publicado: (2017)

Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis
por: Korotkova, M, et al.
Publicado: (2008)

Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas
por: Kiss, Nimrod B, et al.
Publicado: (2012)

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1
por: Zhou, Jiping, et al.
Publicado: (2012)

Upregulation of prostaglandin E(2) by inducible microsomal prostaglandin E synthase-1 in colon cancer
por: Kim, Young Hun, et al.
Publicado: (2022)

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
por: Snapkov, Igor, et al.
Publicado: (2016)

Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
por: Afif, H, et al.
Publicado: (2004)

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1
por: Cao, Long-Long, et al.
Publicado: (2019)

Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice
por: Gurusamy, Malarvizhi, et al.
Publicado: (2021)

Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade
por: Eissler, Nina, et al.
Publicado: (2016)

An Update of Microsomal Prostaglandin E Synthase-1 and PGE(2) Receptors in Cardiovascular Health and Diseases
por: Yang, Guangrui, et al.
Publicado: (2016)

Microsomal Prostaglandin E Synthase-1 Deficiency Exacerbates Pulmonary Fibrosis Induced by Bleomycin in Mice
por: Wei, Bo, et al.
Publicado: (2014)

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells In Vitro
por: Tümmler, Conny, et al.
Publicado: (2019)

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
por: Bergqvist, Filip, et al.
Publicado: (2019)

Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation
por: Treis, Diana, et al.
Publicado: (2022)

Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo
por: Kats, Anna, et al.
Publicado: (2013)

Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E(2) Production
por: Bergqvist, Filip, et al.
Publicado: (2020)

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma
por: Dyberg, Cecilia, et al.
Publicado: (2016)

Pharmacological Characterization of the Microsomal Prostaglandin E(2) Synthase-1 Inhibitor AF3485 In Vitro and In Vivo
por: Di Francesco, Luigia, et al.
Publicado: (2020)

Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease
por: Kotsos, Dimitrios, et al.
Publicado: (2023)

High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in Mice
por: Milosevic, Jelena, et al.
Publicado: (2021)

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
por: Kamei, Daisuke, et al.
Publicado: (2009)

Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia
por: Mukai, Manabu, et al.
Publicado: (2018)

Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective
por: Yasmen, Nelufar, et al.
Publicado: (2023)

Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E(2) synthase up-regulation for colorectal cancer progression
por: Stamatakis, Konstantinos, et al.
Publicado: (2015)

Filamin A increases aggressiveness of human neuroblastoma
por: Bandaru, Sashidar, et al.
Publicado: (2022)

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)
por: Hammarberg, Tove, et al.
Publicado: (2009)

Biosynthesis of prostaglandin 15dPGJ(2) -glutathione and 15dPGJ(2)-cysteine conjugates in macrophages and mast cells via MGST3
por: Steinmetz-Späh, Julia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cst49urqica8q3rl6n5atshl95