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The effect of oral dabigatran etexilate on bone density, strength, and microstructure in healthy mice

Thrombin is a key component in the coagulation cascade where it converts factor V, VIII, XI, and fibrinogen. In addition to the abundant production of thrombin in the liver, osteoclasts synthesize and secrete thrombin as well. Osteoblasts express thrombin receptors, and it has been reported that thr...

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Detalles Bibliográficos
Autores principales: Brent, Mikkel Bo, Thomsen, Jesper Skovhus, Brüel, Annemarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021300/
https://www.ncbi.nlm.nih.gov/pubmed/29963600
http://dx.doi.org/10.1016/j.bonr.2017.12.001