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Cancer cell death induced by ferritins and the peculiar role of their labile iron pool

Cellular uptake of human H-ferritin loaded with 50 or 350 iron ions results in significant cytotoxicity on HeLa cells at submicromolar concentrations. Conversely, Horse Spleen Ferritin, that can be considered a model of L-cages, as it contains only about 10% of H subunits, even when loaded with 1000...

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Detalles Bibliográficos
Autores principales:	Cutrin, Juan Carlos, Alberti, Diego, Bernacchioni, Caterina, Ciambellotti, Silvia, Turano, Paola, Luchinat, Claudio, Crich, Simonetta Geninatti, Aime, Silvio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021343/ https://www.ncbi.nlm.nih.gov/pubmed/29963255 http://dx.doi.org/10.18632/oncotarget.25416

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