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The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data

Clinical trial data are the gold standard for evaluating pharmaceutical safety and efficacy. There is an ethical and scientific imperative for transparency and data sharing to confirm published results and generate new knowledge. The Open Translational Science in Schizophrenia (OPTICS) Project was a...

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Autores principales: Wilcox, Marsha A., Savitz, Adam J., Addington, Anjené M., Gray, Gary S., Guinan, Eva C., Jackson, John W., Lehner, Thomas, Normand, Sharon-Lise, Ranu, Hardeep, Senthil, Geetha, Spertus, Jake, Valeri, Linda, Ross, Joseph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021398/
https://www.ncbi.nlm.nih.gov/pubmed/29950580
http://dx.doi.org/10.1038/s41537-018-0055-7
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author Wilcox, Marsha A.
Savitz, Adam J.
Addington, Anjené M.
Gray, Gary S.
Guinan, Eva C.
Jackson, John W.
Lehner, Thomas
Normand, Sharon-Lise
Ranu, Hardeep
Senthil, Geetha
Spertus, Jake
Valeri, Linda
Ross, Joseph S.
author_facet Wilcox, Marsha A.
Savitz, Adam J.
Addington, Anjené M.
Gray, Gary S.
Guinan, Eva C.
Jackson, John W.
Lehner, Thomas
Normand, Sharon-Lise
Ranu, Hardeep
Senthil, Geetha
Spertus, Jake
Valeri, Linda
Ross, Joseph S.
author_sort Wilcox, Marsha A.
collection PubMed
description Clinical trial data are the gold standard for evaluating pharmaceutical safety and efficacy. There is an ethical and scientific imperative for transparency and data sharing to confirm published results and generate new knowledge. The Open Translational Science in Schizophrenia (OPTICS) Project was an open-science initiative aggregating Janssen clinical trial and NIH/NIMH data from real-world studies and trials in schizophrenia. The project aims were to show the value of using shared data to examine: therapeutic safety and efficacy; disease etiologies and course; and methods development. The success of project investigators was due to collaboration from project applications through analyses, with support from the Harvard Catalyst. Project work was independent of Janssen; all intellectual property was dedicated to the public. Efforts such as this are necessary to gain deeper insights into the biology of disease, foster collaboration, and to achieve the goal of developing better treatments, reducing the overall public health burden of devastating brain diseases.
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spelling pubmed-60213982018-07-05 The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data Wilcox, Marsha A. Savitz, Adam J. Addington, Anjené M. Gray, Gary S. Guinan, Eva C. Jackson, John W. Lehner, Thomas Normand, Sharon-Lise Ranu, Hardeep Senthil, Geetha Spertus, Jake Valeri, Linda Ross, Joseph S. NPJ Schizophr Perspective Clinical trial data are the gold standard for evaluating pharmaceutical safety and efficacy. There is an ethical and scientific imperative for transparency and data sharing to confirm published results and generate new knowledge. The Open Translational Science in Schizophrenia (OPTICS) Project was an open-science initiative aggregating Janssen clinical trial and NIH/NIMH data from real-world studies and trials in schizophrenia. The project aims were to show the value of using shared data to examine: therapeutic safety and efficacy; disease etiologies and course; and methods development. The success of project investigators was due to collaboration from project applications through analyses, with support from the Harvard Catalyst. Project work was independent of Janssen; all intellectual property was dedicated to the public. Efforts such as this are necessary to gain deeper insights into the biology of disease, foster collaboration, and to achieve the goal of developing better treatments, reducing the overall public health burden of devastating brain diseases. Nature Publishing Group UK 2018-06-27 /pmc/articles/PMC6021398/ /pubmed/29950580 http://dx.doi.org/10.1038/s41537-018-0055-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Wilcox, Marsha A.
Savitz, Adam J.
Addington, Anjené M.
Gray, Gary S.
Guinan, Eva C.
Jackson, John W.
Lehner, Thomas
Normand, Sharon-Lise
Ranu, Hardeep
Senthil, Geetha
Spertus, Jake
Valeri, Linda
Ross, Joseph S.
The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data
title The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data
title_full The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data
title_fullStr The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data
title_full_unstemmed The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data
title_short The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data
title_sort open translational science in schizophrenia (optics) project: an open-science project bringing together janssen clinical trial and nimh data
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021398/
https://www.ncbi.nlm.nih.gov/pubmed/29950580
http://dx.doi.org/10.1038/s41537-018-0055-7
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