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Cancer risk by the subtype of alopecia
The cancer risk in patients with alopecia areata (AA) or alopecia totalis (AT)/alopecia universalis (AU) remains unknown. In this study, national statistical data were used to study the association between these forms of alopecia and the risk of cancer. We enrolled 668,604 patients who were treated...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021412/ https://www.ncbi.nlm.nih.gov/pubmed/29950587 http://dx.doi.org/10.1038/s41598-018-28142-1 |
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author | Lee, Ji Hyun Song, Yumee Do Han, Kyung Park, Young Min Lee, Jun Young Park, Yong-Gyu Lee, Young Bok |
author_facet | Lee, Ji Hyun Song, Yumee Do Han, Kyung Park, Young Min Lee, Jun Young Park, Yong-Gyu Lee, Young Bok |
author_sort | Lee, Ji Hyun |
collection | PubMed |
description | The cancer risk in patients with alopecia areata (AA) or alopecia totalis (AT)/alopecia universalis (AU) remains unknown. In this study, national statistical data were used to study the association between these forms of alopecia and the risk of cancer. We enrolled 668,604 patients who were treated for alopecia from 2007 to 2014, and age- and sex-matched control subjects. AA and AT/AU patients had slightly higher overall cancer risks (hazard ratio (HR), 1.043; 95% confidence interval (CI), 1.022–1.065 and HR, 1.07; 95% CI, 1.013–1.129, respectively) than controls, after adjusting for confounding factors. The risks of oral cavity, esophagus, liver, biliary tract, pancreas, larynx, lung, kidney, breast, cervix, ovary, uterus, testis, nerve, and skin cancers; and lymphoma, multiple myeloma, and leukemia, were not increased in alopecia patients. In AA or AT/AU patients, the only increased risk was that of thyroid cancer. In AA patients alone, the risks of bladder and prostate cancers were increased. Thus, the cancer risks varied by the alopecia subtype. Careful monitoring is needed to explore if the actual risks of thyroid, bladder, and prostate cancers are increased in alopecia patients. |
format | Online Article Text |
id | pubmed-6021412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60214122018-07-06 Cancer risk by the subtype of alopecia Lee, Ji Hyun Song, Yumee Do Han, Kyung Park, Young Min Lee, Jun Young Park, Yong-Gyu Lee, Young Bok Sci Rep Article The cancer risk in patients with alopecia areata (AA) or alopecia totalis (AT)/alopecia universalis (AU) remains unknown. In this study, national statistical data were used to study the association between these forms of alopecia and the risk of cancer. We enrolled 668,604 patients who were treated for alopecia from 2007 to 2014, and age- and sex-matched control subjects. AA and AT/AU patients had slightly higher overall cancer risks (hazard ratio (HR), 1.043; 95% confidence interval (CI), 1.022–1.065 and HR, 1.07; 95% CI, 1.013–1.129, respectively) than controls, after adjusting for confounding factors. The risks of oral cavity, esophagus, liver, biliary tract, pancreas, larynx, lung, kidney, breast, cervix, ovary, uterus, testis, nerve, and skin cancers; and lymphoma, multiple myeloma, and leukemia, were not increased in alopecia patients. In AA or AT/AU patients, the only increased risk was that of thyroid cancer. In AA patients alone, the risks of bladder and prostate cancers were increased. Thus, the cancer risks varied by the alopecia subtype. Careful monitoring is needed to explore if the actual risks of thyroid, bladder, and prostate cancers are increased in alopecia patients. Nature Publishing Group UK 2018-06-27 /pmc/articles/PMC6021412/ /pubmed/29950587 http://dx.doi.org/10.1038/s41598-018-28142-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lee, Ji Hyun Song, Yumee Do Han, Kyung Park, Young Min Lee, Jun Young Park, Yong-Gyu Lee, Young Bok Cancer risk by the subtype of alopecia |
title | Cancer risk by the subtype of alopecia |
title_full | Cancer risk by the subtype of alopecia |
title_fullStr | Cancer risk by the subtype of alopecia |
title_full_unstemmed | Cancer risk by the subtype of alopecia |
title_short | Cancer risk by the subtype of alopecia |
title_sort | cancer risk by the subtype of alopecia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021412/ https://www.ncbi.nlm.nih.gov/pubmed/29950587 http://dx.doi.org/10.1038/s41598-018-28142-1 |
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