Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation

Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are fo...

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Detalles Bibliográficos
Autores principales: Wakae, Kousho, Nishiyama, Tomoaki, Kondo, Satoru, Izuka, Takashi, Que, Lusheng, Chen, Cong, Kase, Kina, Kitamura, Kouichi, Mohiuddin, Md, Wang, Zhe, Ahasan, Md Monjurul, Nakamura, Mitsuhiro, Fujiwara, Hiroshi, Yoshizaki, Tomokazu, Hosomochi, Kazuyoshi, Tajima, Atsushi, Nakahara, Tomomi, Kiyono, Tohru, Muramatsu, Masamichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021414/
https://www.ncbi.nlm.nih.gov/pubmed/29950685
http://dx.doi.org/10.1038/s41598-018-27930-z

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