Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

Vital mitochondrial DNA (mtDNA) populations exist in cells and may consist of heteroplasmic mixtures of mtDNA types. The evolution of these heteroplasmic populations through development, ageing, and generations is central to genetic diseases, but is poorly understood in mammals. Here we dissect thes...

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Detalles Bibliográficos
Autores principales: Burgstaller, Joerg P., Kolbe, Thomas, Havlicek, Vitezslav, Hembach, Stephanie, Poulton, Joanna, Piálek, Jaroslav, Steinborn, Ralf, Rülicke, Thomas, Brem, Gottfried, Jones, Nick S., Johnston, Iain G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021422/
https://www.ncbi.nlm.nih.gov/pubmed/29950599
http://dx.doi.org/10.1038/s41467-018-04797-2

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