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KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency of somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Treatment of relapsed aGCT remains a significant clinical challenge. Here we show, using whole-exome and cancer gene panel sequencing...

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Detalles Bibliográficos
Autores principales:	Hillman, R. Tyler, Celestino, Joseph, Terranova, Christopher, Beird, Hannah C., Gumbs, Curtis, Little, Latasha, Nguyen, Tri, Thornton, Rebecca, Tippen, Samantha, Zhang, Jianhua, Lu, Karen H., Gershenson, David M., Rai, Kunal, Broaddus, Russell R., Futreal, P. Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021426/ https://www.ncbi.nlm.nih.gov/pubmed/29950560 http://dx.doi.org/10.1038/s41467-018-04950-x

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