Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria

Methods to regulate gene expression programs in bacterial cells are limited by the absence of effective gene activators. To address this challenge, we have developed synthetic bacterial transcriptional activators in E. coli by linking activation domains to programmable CRISPR-Cas DNA binding domains...

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Detalles Bibliográficos
Autores principales: Dong, Chen, Fontana, Jason, Patel, Anika, Carothers, James M., Zalatan, Jesse G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021436/
https://www.ncbi.nlm.nih.gov/pubmed/29950558
http://dx.doi.org/10.1038/s41467-018-04901-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021436/
https://www.ncbi.nlm.nih.gov/pubmed/29950558
http://dx.doi.org/10.1038/s41467-018-04901-6

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