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Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
Methods to regulate gene expression programs in bacterial cells are limited by the absence of effective gene activators. To address this challenge, we have developed synthetic bacterial transcriptional activators in E. coli by linking activation domains to programmable CRISPR-Cas DNA binding domains...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021436/ https://www.ncbi.nlm.nih.gov/pubmed/29950558 http://dx.doi.org/10.1038/s41467-018-04901-6 |