Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume

In this report, Chair Heterogeneity Index (CHI) was introduced to assess the dose heterogeneity inside the target with a boost volume. CHI was defined by dividing (V(Rx) − V(Dl)) by (V(Dm) − V(Dh)): V(Rx), V(Dl), V(Dm) and V(Dh) were four points selected from the target cumulative dose volume histog...

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Autores principales: Mu, Jinming, Xi, Dan, Ding, Yun, Gu, Wendong, Li, Qilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021440/
https://www.ncbi.nlm.nih.gov/pubmed/29950564
http://dx.doi.org/10.1038/s41598-018-28110-9
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author Mu, Jinming
Xi, Dan
Ding, Yun
Gu, Wendong
Li, Qilin
author_facet Mu, Jinming
Xi, Dan
Ding, Yun
Gu, Wendong
Li, Qilin
author_sort Mu, Jinming
collection PubMed
description In this report, Chair Heterogeneity Index (CHI) was introduced to assess the dose heterogeneity inside the target with a boost volume. CHI was defined by dividing (V(Rx) − V(Dl)) by (V(Dm) − V(Dh)): V(Rx), V(Dl), V(Dm) and V(Dh) were four points selected from the target cumulative dose volume histogram curve. The effectiveness of CHI was validated by assessing the treatment plans for nasopharyngeal cancer (NPC, 12 cases), breast cancer after breast-conserving-surgery (BC, 10 cases), and stereotactic radiosurgery after whole brain irradiation (SRS, 9 cases). Our results indicate that both CHI and HI of the target can distinguish Volumetric Modulated Arc Therapy (VMAT) from Intensity Modulated Radiation Therapy (IMRT, p < 0.05) while the mean differences in CHI (NPC 1.16, BC 1.19 and SRS 3.3) were larger than those in HI (NPC 0.03, BC 0.02 and SRS 0.02). In addition, CHI of the combination volume (the target minus the boost) were statistically higher in VMAT than IMRT in all three kinds of cancer. In conclusion, CHI was effective in assessing the dose heterogeneity inside a target containing a boost volume.
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spelling pubmed-60214402018-07-06 Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume Mu, Jinming Xi, Dan Ding, Yun Gu, Wendong Li, Qilin Sci Rep Article In this report, Chair Heterogeneity Index (CHI) was introduced to assess the dose heterogeneity inside the target with a boost volume. CHI was defined by dividing (V(Rx) − V(Dl)) by (V(Dm) − V(Dh)): V(Rx), V(Dl), V(Dm) and V(Dh) were four points selected from the target cumulative dose volume histogram curve. The effectiveness of CHI was validated by assessing the treatment plans for nasopharyngeal cancer (NPC, 12 cases), breast cancer after breast-conserving-surgery (BC, 10 cases), and stereotactic radiosurgery after whole brain irradiation (SRS, 9 cases). Our results indicate that both CHI and HI of the target can distinguish Volumetric Modulated Arc Therapy (VMAT) from Intensity Modulated Radiation Therapy (IMRT, p < 0.05) while the mean differences in CHI (NPC 1.16, BC 1.19 and SRS 3.3) were larger than those in HI (NPC 0.03, BC 0.02 and SRS 0.02). In addition, CHI of the combination volume (the target minus the boost) were statistically higher in VMAT than IMRT in all three kinds of cancer. In conclusion, CHI was effective in assessing the dose heterogeneity inside a target containing a boost volume. Nature Publishing Group UK 2018-06-27 /pmc/articles/PMC6021440/ /pubmed/29950564 http://dx.doi.org/10.1038/s41598-018-28110-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mu, Jinming
Xi, Dan
Ding, Yun
Gu, Wendong
Li, Qilin
Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume
title Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume
title_full Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume
title_fullStr Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume
title_full_unstemmed Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume
title_short Chair Heterogeneity Index: Describing the dose heterogeneity inside the tumor volume where there is a boost volume
title_sort chair heterogeneity index: describing the dose heterogeneity inside the tumor volume where there is a boost volume
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021440/
https://www.ncbi.nlm.nih.gov/pubmed/29950564
http://dx.doi.org/10.1038/s41598-018-28110-9
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AT dingyun chairheterogeneityindexdescribingthedoseheterogeneityinsidethetumorvolumewherethereisaboostvolume
AT guwendong chairheterogeneityindexdescribingthedoseheterogeneityinsidethetumorvolumewherethereisaboostvolume
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