First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils

PURPOSE: Administration of therapeutic monoclonal antibodies (mAbs) is frequently accompanied by severe first infusion reactions (FIR). The mechanism driving FIR is still unclear. This study aimed to investigate the cellular and molecular mechanisms causing FIR in humanized mouse models and their po...

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Detalles Bibliográficos
Autores principales: Weber, Felix, Breustedt, Daniel, Schlicht, Sonja, Meyer, Claas A., Niewoehner, Jens, Ebeling, Martin, Freskgard, Per-Ola, Bruenker, Peter, Singer, Thomas, Reth, Michael, Iglesias, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021477/
https://www.ncbi.nlm.nih.gov/pubmed/29951887
http://dx.doi.org/10.1007/s11095-018-2448-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021477/
https://www.ncbi.nlm.nih.gov/pubmed/29951887
http://dx.doi.org/10.1007/s11095-018-2448-8

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