Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages

Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for NLRP3-inflammasome assembly and, consequently, for mature IL-1β generation after mycobacterial infection in vitro. Elev...

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Detalles Bibliográficos
Autores principales: Amaral, Eduardo P., Riteau, Nicolas, Moayeri, Mahtab, Maier, Nolan, Mayer-Barber, Katrin D., Pereira, Rosana M., Lage, Silvia L., Kubler, Andre, Bishai, William R., D’Império-Lima, Maria R., Sher, Alan, Andrade, Bruno B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021483/
https://www.ncbi.nlm.nih.gov/pubmed/29977244
http://dx.doi.org/10.3389/fimmu.2018.01427

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